Two Cases Report of Intrathecal Tigecycline Therapy for Intracranial Infection with Acinetobacter baumannii and Review of Literatures

Abstract

Objective: To explore the treatment scheme for intracranial infection with Acinetobacter baumannii. Methods: We retrospective analyzed two cases of patients of intracranial infection with Acinetobacter baumannii. Results: The intracranial infection was controlled effectively by the scheme to intravenous“tigecycline + cefperazone-sulbactam”combined with intrathecal tigecycline injection, the two patients recover well with 21 months’ follow-up. Conclusions: Tigecycline-based drug scheme combined with intrathecal tigecycline injection can achieve the effect of controlling intracranial infection. Lumbar cisterna drainage tube plays a major role in controlling intracranial infection.

Keywords:

• multidrug resistant Acinetobacter baumannii
• intracranial infection
• tigecycline

Patient Consent and Ethics Statement

Both patients provided informed consent for the case details and images to be published. No ethical committee approval was required for this study as the data had been analyzed in a retrospective manner.

Disclosure

The authors report no conflicts of interest in this work.