https://orcid.org/0000-0001-9573-3431
![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Objective
To investigate drug resistance and homology of pathogens that can cause infective diarrhea in East Heilongjiang, China, and provide suitable references for the clinical treatment.
Methods
The process of isolation and identification of pathogenic bacteria in the faeces and blood of diarrhea patients was conducted. The drug resistance of the isolated pathogenic bacteria was analyzed by VITEK 2 compact drug sensitivity analysis system, and the strain homology was determined by pulsed field gel electrophoresis (PFGE).
Results
From 2014 to 2018, 28 different strains of pathogenic bacteria were isolated from 657 samples of faeces and blood, including 23 strains of Salmonella, 3 strains of Vibrio parahaemolyticus and 2 strains of diarrheal Escherichia coli, with detection rates of 3.5%, 0.46% and 0.30% respectively. Among them, 22 strains of Salmonella exhibited significant drug resistance, with a drug resistance rate of 95.65%. A total of 11 different PFGE fingerprints of 23 Salmonella strains were also obtained, with a homology of 56.5–100%.
Conclusion
Among the various pathogens causing infective diarrhea in East Heilongjiang, China, Salmonella displayed multiple drug resistance and its distribution was found to be polymorphic.
Keywords:
Data Sharing Statement
The data used to support the findings of this study are included within the article.
Ethics Approval and Consent to Participate
All the protocols were approved by the Ethics Committee of Jiamusi University Clinical Medical College (0378). Patient informed consent was waived as the samples were collected from existing specimens retrieved during routine procedures and did not require further involvement from patients. For patients who were actively screened, we obtained oral consent from the patients.
Author Contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis, drafting and revising the article, gave final approval of the version to be published, have agreed on the journal to which the article will be submitted and agreed to be accountable for all aspects of the work. The final manuscript was reviewed and approved by all authors.
Disclosure
The authors have no competing interests.