Abstract
Objective
To analyze the infection and distribution of multidrug-resistant organisms (MDRO) in different clinical specimens, thereby providing a reference for clinical diagnosis and treatment and prevention and control.
Patient and Methods
2314 strains of MDRO isolated from clinical specimens in the First Affiliated Hospital of Nanjing Medical University from January to December 2020. MDRO were collected by Information System. The detection rate of MDRO, infection rate, the proportion of infection, and detection rate of MDRO infection in different specimens were analyzed.
Results
The top three specimens in the detection rate of MDRO were BALF (60.71%), sputum (33.68%), and blood (28.79%). The top three specimens in the proportion of MDRO infection were blood (97.74), other sterile body fluids (90.35%), and BALF (90.20%). The top three specimens in the MDRO infection rate were BALF (9.75%), sputum (3.07%), and secretions (2.90%). The top three specimens in the detection rate of MDRO infection were sputum (0.63‰), other sterile body fluids (0.13‰), and secretions (0.11‰).
Conclusion
The detection and infection distribution of MDRO vary greatly in different specimens. The submission of sterile body fluids for examination should be strengthened and the standard of sample collection should be highlighted.
Abbreviation
MDRO, Multidrug-resistant organisms; MRSA, Methicillin-Resistant Staphylococcus Aureus; CRE, Carbapenem-Resistant Enterobacteriaceae; CRPA, Carbapenem-Resistant Pseudomonas Aeruginosa; LIS, Laboratory Information System; CLSL, Clinical and Laboratory Standards Institute; WBC, White blood cell count; CRKP, Carbapenem-resistant Klebsiella Pneumoniae; ICU, Intensive Care Unit.
Data Sharing Statement
The data used to support the findings of this study are available from the corresponding author upon request.
Ethical Statement
We carried out this study according to the revised Declaration of Helsinki, and this study was approved by the hospital ethics committee and exempted from informed consent (2019-SR-075).Because the study was retrospective and the study followed only the drug resistance of the specimens and did not involve other information about the patients, the ethical application for exemption from informed consent was passed.
Acknowledgment
We would like to acknowledge the reviewers for their helpful comments on this paper.
Author Contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work. Zhanjie Li and Ying Zhang are co-first authors.
Disclosure
The authors declare no conflicts of interest in this work.