Efinaconazole in the treatment of onychomycosis

Abstract

Efinaconazole 10% topical solution is a new triazole recently approved for the treatment of onychomycosis. It inhibits fungal lanosterol 14α-demethylase in the ergosterol biosynthesis pathway, has potent antifungal activity against dermatophytes, as well as activity against Candida spp. and non-dermatophyte molds, and showed promising results in clinical trials. This review summarizes the mechanism of action, in vitro and in vivo data, clinical trials, safety, and quality-of-life data of efinaconazole as it applies to the treatment of onychomycosis.

Keywords:

• efinaconazole
• Jublia
• onychomycosis
• fungal infection
• nail infection

Disclosure

Dr Lipner has no conflicts of interest to disclose. Dr Scher is a consultant, investigator, and speaker for multiple companies including consultant and speaker for Valeant. The authors report no other conflicts of interest in this work.