Parecoxib relieves pain and has an opioid-sparing effect following major gastrointestinal surgery

Abstract

Purpose

Parecoxib provides analgesia following a variety of surgeries, including minor gastrointestinal procedures. To our knowledge, there is no data on parecoxib following major gastrointestinal surgery. This study assessed the efficacy and opioid-sparing effects of parecoxib following major gastrointestinal surgeries.

Patients and methods

Patients in this analysis were a subset from a large, randomized, double-blind, placebo-controlled trial of parecoxib following noncardiac surgeries and consisted of those undergoing a variety of major gastrointestinal surgeries via laparotomy. Pain, pain interference with function, supplemental opioid utilization, opioid-related symptoms, and Patient/Physician Global Evaluation of Study Medication were compared between placebo and parecoxib groups in the 2−3 days following surgery.

Results

Significantly (p<0.001) lower pain scores were observed in the parecoxib group (n=111), relative to placebo (n=126), on Day 2 (−33%) and Day 3 (−35%). Pain interference with function scores was also significantly (p<0.001) lower among patients receiving parecoxib compared with placebo on Day 2 (−29%) and Day 3 (−36%). At 24, 48, and 72 hours, the cumulative amount of supplemental morphine consumed was 45%, 41%, and 40% less in patients receiving parecoxib compared with placebo (all p<0.001). The risk of experiencing ≥1 opioid-related symptoms was also significantly lower with parecoxib than with placebo on Day 2 (relative risk=0.75; p<0.001). Specifically, the risks of fatigue and drowsiness were significantly (both p<0.05) lower in patients receiving parecoxib compared to those receiving placebo. Patient and Physician Global Evaluation of Study Medication scores were significantly better in the parecoxib group than in the placebo group (p<0.001).

Conclusion

This study is the first to demonstrate that multiple-dose parecoxib, initiated upon recovery from anesthesia, provides analgesia and opioid-sparing effects following a variety of major gastrointestinal surgeries employing laparotomy.

Keywords:

• parecoxib
• gastrointestinal
• laparotomy
• postoperative pain
• opioid sparing

Supplementary material

Table S1 List of institutional review board or ethics committees approving the study

Acknowledgments

This study was sponsored by Pfizer. Medical writing support was provided by Matt Soulsby PhD, CMPP, of Engage Scientific Solutions and was funded by Pfizer.

Disclosure

MNE, BP, and CL are full-time employees of, and own stock in, Pfizer. LX was a full-time employee of Pfizer at the time the work was done; current affiliation is Takeda Pharmaceutical (China) Company Limited. The authors report no other conflicts of interest in this work.