A Study on the Correlation Between MDR1 Polymorphism and Clopidogrel Resistance in Hui Patients Treated with Percutaneous Coronary Intervention

Abstract

Objective

This study assesses the correlation between MDR1 gene polymorphism and clopidogrel resistance (CR) in Hui patients with coronary heart disease (CHD) who were treated with percutaneous coronary intervention (PCI).

Methods

The study includes 204 Ningxia Hui patients with CHD who were treated with PCI. These patients were divided into two groups: those who with CR and others were non-clopidogrel resistant (NCR), according to the results of the patients’ platelet aggregation rate, which was tested by adenosine diphosphate-induced turbidimetry on the second postoperative day. C3435T and C1236T genotypes and alleles were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results

The CR rate was 24.0%, and there were 3 genotypes of C3435T and C1236T. For C3435T, the distribution frequency of the 3435TT genotype and T allele was significantly higher in the CR group than in the NCR group. For C1236T, no significant difference was found between the two groups.

Conclusion

Hui patients who had CHD were treated with PCI. CR was most likely to occur in those who had the T allele of MDR1 in gene C3435T.

Keywords:

• coronary heart disease
• MDR1 gene
• clopidogrel resistance
• gene polymorphism
• platelet aggregation rate

Data Sharing Statement

We declared that materials described in the manuscript, including all relevant raw data, will be freely available to any scientists who wish to use them for non-commercial purposes without breaching participants’ confidentiality.

Ethics Approval and Consent to Participation

This study was conducted with approval of the Ethics Committee of Yinchuan First People’s Hospital. This study was conducted in accordance with the declaration of Helsinki. Written informed consent has been obtained from all participants.

Consent for Publication

All participants have signed documents with informed consent.

Acknowledgments

We are particularly grateful to all the people who have offered us help on our articles.

Disclosure

The authors declare that they have no competing interests.

Additional information

Funding

Source of supports: Ningxia Science and Technology Support Project (Grant No. 2012ZYS212). The funding body plays no role in designing the studies and collections, analysis, and interpretation of data and writing the manuscript as well.