Assessment of Computed Tomography-Defined Muscle and Adipose Tissue Features in Relation to Length of Hospital Stay and Recurrence of Hypertriglyceridemic Pancreatitis

Abstract

Background

Analytic morphometric assessment has recently been proposed to be applied to the study of acute pancreatitis (AP). However, the relationship between body composition and the outcomes of hypertriglyceridemic pancreatitis (HTGP) is still unclear. The aim of this study was to evaluate body composition in relation to the length of hospital stay (LOS) and recurrence of HTGP.

Methods

Patient characteristics, admission examination data, body composition parameters, LOS, and recurrence within 1 year were collected from the institutional pancreatitis database and follow-up records. Logistic regression analysis was used to identify risk factors for LOS and recurrence of HTGP.

Results

Of the 196 included patients, 158 (80.6%) were men and 53 (27.0%) were sarcopenic. The average LOS was 15.83±10.02 days. The recurrence rate of HTGP was 36.7%. Multivariate analysis with multiple linear regression suggested that subcutaneous adipose tissue (SAT) area (p=0.019) and high-density lipoprotein-cholesterol (HDL-C) (p=0.001) were independently associated with the LOS for HTGP after adjusting for age and sex. The multivariate adjusted hazard ratios for SAT area and HDL-C, with respect to the relationship between body parameters and LOS, were 1.008 (95% confidence interval [CI], 1.001–1.015) and 0.090 (95% CI, 0.022–0.361), respectively. No significant differences were observed between the AP and recurrent AP (RAP) groups in terms of characteristics, admission examination data, and body composition parameters.

Conclusion

SAT area and HDL-C are associated with LOS in patients with HTGP. The body composition of patients at the first symptom onset of HTGP cannot predict recurrence.

Keywords:

• hypertriglyceridemic pancreatitis
• recurrent pancreatitis
• length of hospital stay
• body composition
• subcutaneous adipose tissue

View correction statement:

Assessment of Computed Tomography-Defined Muscle and Adipose Tissue Features in Relation to Length of Hospital Stay and Recurrence of Hypertriglyceridemic Pancreatitis [Corrigendum]

Ethics Approval and Consent to Participate

The study protocol was approved by the ethics committee of the First Affiliated Hospital of Wenzhou Medical University (KY2019–011). The ethics committee did not require patients to consent to review their medical records due to the retrospective nature of the study and the study poses a very low risk to the patients. This study was conducted in accordance with the declaration of Helsinki 1975, revised Hong Kong 1989. And the confidentiality and anonymity of the data was also ensured.

Disclosure

The authors have no conflicts of interest to declare.

Additional information

Funding

This research was partially funded by a grant from Wenzhou Science and Technology Planning Project (CN), project number: 2019Y0062.