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Abstract
Objective
The prevalence of hyperuricemia appears to be high worldwide. We aimed to explore the interaction between harmful alcohol use and tea consumption on hyperuricemia.
Methods
This study recruited 22,449 Han residents based on the data from the China Multi-Ethnic Cohort (CMEC) study, Chongqing province, to have a face-to-face electronic questionnaire, physical examination, and clinical laboratory tests. The difference in hyperuricemia between the different populations was compared by the Chi-square test. The interaction between harmful alcohol use and tea consumption was analyzed by the multivariate logistic regression model.
Results
Amongst 22,449 participants, the mean age was 51.5±11.8 years, and 46.83% of them were males. The proportion of harmful alcohol use, tea consumption, and harmful alcohol use and tea consumption were 14.01%, 21.01%, and 6.54%, respectively. Multivariate logistic regression showed that the odds ratio (OR) of harmful alcohol use and tea consumption (OR=2.21, 95% CI: 1.58–3.10) was greater than that of harmful alcohol use (OR=1.63, 95% CI:1.17–2.27) and tea consumption (OR=1.34, 95% CI:1.10–1.63). Among males, the results were similar (harmful alcohol use and tea consumption: OR=2.02, 95% CI: 1.43–2.84; harmful alcohol use: OR=1.61, 95% CI: 1.14–2.27; tea consumption: OR=1.28, 95% CI: 1.05–1.57). However, among females, the odds ratio of harmful alcohol use and tea consumption (OR=15.50, 95% CI: 1.36–176.50) was more than 10 times than that of only harmful alcohol use (OR=1.55, 95% CI: 0.42–5.69) or tea consumption (OR=1.22, 95% CI: 0.52–2.82).
Conclusion
The interaction of harmful alcohol use and tea consumption was a positive risk for hyperuricemia in Han residents aged 30–79 years in China.
Abbreviations
HU, hyperuricemia; SUA, serum uric acid; CMEC, China Multi-Ethnic Cohort; OR, odds ratios; CI, confidence interval.
Data Sharing Statement
The data supporting the findings of this study are available from the corresponding author upon reasonable request.
Ethics Approval and Informed Consent
The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Research Ethics Committee of the Chongqing Centre for Disease Control and Prevention (No. 2017 (001)). All study participants provided informed consent. All methods were performed in accordance with the relevant guidelines and regulations.
Acknowledgments
We really appreciate all the participants in this study, and thanks for the support of all the team members for this study.
Author Contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Disclosure
The authors declare that they have no competing interests in this work.