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RESPONSE TO LETTER

Depths of Malignancy: On the Prognosis of Breast Cancer [Response to Letter]

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Pages 1807-1808 | Received 04 Apr 2023, Accepted 06 Apr 2023, Published online: 15 May 2023
This article responds to:
Depths of Malignancy: On the Prognosis of Breast Cancer [Letter]

Dear editor

We are honored that our published article has been read and paid attention by many people. In the following, I will explain one by one according to the reader’s questions.

Firstly, none of the patients were lactating women. Secondly, as mentioned in the article, this study was only a single-center study, and the sample size (134 cases) may not be sufficient to fully reflect the status of breast cancer patients. Meanwhile, it is short of follow-up time and lacks OS. Median follow-up time was 45 months and most postoperative breast cancer patients often confront the first peak time of recurrence before 36 months.Citation1 Due to the credible and complete quantitative data on PFS, the value of LAR for the prognosis of breast cancer patients is compelling and sufficient, especially for those who may suffer the first recurrent peak. Thirdly, C-reactive protein is a vital inflammatory marker and I think it would be a good research direction. Finally, lymphatic fluid is less accessible than blood, so we selected blood as a medium.

Disclosure

The authors report no conflicts of interest in this communication.

Reference

  • Ribelles N, Perez-Villa L, Jerez JM, et al. Pattern of recurrence of early breast cancer is different according to intrinsic subtype and proliferation index. Breast Cancer Res. 2013;15(5):R98. doi:10.1186/bcr3559