Abstract
Purpose
The effects of combing evolocumab and statin on the clinical outcome and physiological function of coronary arteries in STEMI patients with non-infarct-related artery (NIRA) disease are still unclear.
Methods
A total of 355 STEMI patients with NIRA were enrolled in this study, who underwent combined quantitative flow ratio (QFR) at baseline and after 12 months of treatment with statin monotherapy or statin plus evolocumab.
Results
Diameter stenosis and lesion length were significantly lower in the group undergoing statin plus evolocumab. While the group exhibited significantly higher minimum lumen diameter (MLD), and QFR values. Statin plus evolocumab (OR = 0.350; 95% CI: 0.149–0.824; P = 0.016) and plaque lesion length (OR = 1.223; 95% CI: 1.102–1.457; P = 0.033) were independently associated with rehospitalization for unstable angina (UA) within 12 months.
Conclusion
Evolocumab combined with statin therapy can significantly improve the anatomical and physiological function of the coronary arteries and downregulate the re-hospitalization rate due to UA in STEMI patients with NIRA.
Data Sharing Statement
Upon reasonable request, the original data can be obtained from the corresponding authors.
Approval of Ethics and Consent to Participate
The ethics committee of 1st Affiliated Hospital of Harbin Medical University has approved the study, which was conducted in view of the principles of the Declaration of Helsinki. Patient consents were obtained in writing by each of participants before participating in the study.
Acknowledgments
Thank you for funding our research. Qi Zhao, Siyuan Sun, and Fanghui Zhou are co-first authors for this study.
Disclosure
The authors report no conflicts of interest in this work.