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Abstract
Nine pretreated patients aged >19 years with relapsed/refractory acute lymphoblastic leukemia (ALL) were treated with a combination of bortezomib plus chemotherapy before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Eight (88.9%) patients, including two Philadelphia chromosome-positive ALL patients, achieved a complete remission. Furthermore, the evaluable patients have benefited from allo-HSCT after response to this reinduction treatment. We conclude that bortezomib-based chemotherapy was highly effective for adults with refractory/relapsed ALL before allo-HSCT. Therefore, this regimen deserves a larger series within prospective trials to confirm these results.
Acknowledgments
The authors would like to thank all patients for their cooperation. This study was supported by grants from the National Natural Science Foundation of China (Number 30900637) and the National Natural Science Foundation of China (Number 81370661).
Author contributions
All authors designed the research, enrolled the study patients, supervised the study, collected clinical data, analyzed the data, and drafted and revised the manuscript.
Disclosure
The authors declare no potential conflicts of interest in this work.