Abstract
Objective:
This study was conducted to determine the distribution of the single nucleotide polymorphism (SNP) at position -1082 of the proximal promoter region of the interleukin (IL)-10 gene and its association with hepatitis virus co-infection in Indonesian Javanese human immunodeficiency virus (HIV)-infected patients.
Methods:
Blood samples were collected from 156 Indonesian Javanese HIV-infected patients; tested with serological and molecular assays for hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV); and subjected to SNP -1082 G/A polymorphism analysis.
Results:
Hepatitis 5 surface antigen (HBsAg) (+)/HBV DNA (+), HBsAg (−)/HBV DNA (+), anti-HCV antibodies (+)/HCV RNA (+), and anti-HCV antibodies (−)/HCV RNA (+) were detected from all of HIV-infected individuals at rates of 3.8% (6/156), 0.6% (1/156), 16.0% (25/156), and 11.5% (18/156), respectively. The frequencies of -1082 GG, -1082 GA, and -1082 AA were 14.7% (23/156), 60.3% (94/156), and 25% (39/156), respectively. HBV co-infection was found only in -1082 A allele carriers, and these patients also showed higher rates of HCV co-infection (odds ratio: 2.24, 95% confidence interval: 1.22–4.10, P=0.009).
Conclusion:
The -1082 A allele was associated with HBV and HCV co-infection in Indonesian Javanese HIV patients.
Keywords::
Acknowledgments
This work was supported in part by grants from the Indonesian Directorate of Higher Education (No 505/SP2H/PL/Dit.Litabmas/VII/2011, No 197/SP2H/PL/Dit.Litabmas/IV/2012, and No 077/SP2H/PL/Dit.Litabmas/V/2013) and from APBN/DIPA UNS (No 2342/UN27.16/PN/2012, No 159a/UN27.11/PN/2013, No 165/UN27.11/PN/2013, No 267a/UN27.16/PN/2013, No 501/UN27.11/PN/2014, No 853/UN27.11/PN/2014, and No 339/UN27.11/PL/2015).
Disclosure
The authors report no conflicts of interest in this work.