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Abstract
Due to their small particle size and large and modifiable surface, nanoparticles have unique advantages compared with other drug carriers. As a research focus in recent years, polyethylene glycol–polylactic acid (PEG–PLA) block copolymer and its end-group derivative nanoparticles can enhance the drug loading of hydrophobic drugs, reduce the burst effect, avoid being engulfed by phagocytes, increase the circulation time of drugs in blood, and improve bioavailability. Additionally, due to their smaller particle size and modified surface, these nanoparticles can accumulate in inflammation or target locations to enhance drug efficacy and reduce toxicity. Recent advances in PEG–PLA block copolymer nanoparticles, including the synthesis of PEG–PLA and the preparation of PEG–PLA nanoparticles, were introduced in this study, in particular the drug release and modifiable characteristics of PEG–PLA nanoparticles and their application in pharmaceutical preparations.
Acknowledgment
This work was supported by grants from the Foundation of Zhejiang Science and Technology Department (2009C33005), National Natural Science Foundation of China (81001647), China Postdoctoral Science Foundation (20100471757), and National Natural Science Foundation of China (20906016).
Disclosure
The authors report no conflicts of interest. The authors are solely responsible for the content and writing of the article.