DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats

Abstract

Aims

Despite daily increase in diabetic patients in the world, currently approved medications for this disease, at best, only reduce its progression speed. Using novel technologies is a solution for synthetizing more efficient medicines. In the present study, we evaluated anti-diabetic effects of DIBc, a nano metal–organic framework, which is synthetized based on nanochelating technology.

Methods

High-fat diet and streptozotocin-induced diabetic rats were treated by DIBc or metformin for 6 weeks.

Results

DIBc decreased plasma glucose, triglyceride, cholesterol, high-density lipoprotein, and low-density lipoprotein compared with diabetic and metformin groups. In DIBc-treated rats, significant homeostasis model assessment of insulin resistance index, malondialdehyde, and tumor necrosis factor-α decrease was observed. H&E staining showed increased islet number and area in DIBc-treated rats compared with diabetic controls.

Conclusion

The results showed anti-diabetic effects of nanochelating-based framework. So DIBc, as a nano structure, has the capacity to be evaluated in future studies as a novel anti-diabetic agent.

Keywords:

• DIBc
• nanochelating technology
• metal organic framework
• diabetes
• streptozotocin
• high-fat diet

Acknowledgments

We thank the Department of Research and Development at Sodour Ahrar Shargh and the Department of Physiology at School of Medicine, Shahid Beheshti University of Medical Sciences, for their kind support in this project.

Disclosure

The authors report no conflicts of interest in this work.