Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends' integration with polyetheretherketone

Abstract

The porous surface of a polyetheretherketone (PK)–nanoporous lithium-doped magnesium silicate (NLS) blend (PKNLS) was fabricated on a PK surface by layer-by-layer pressuring, sintering, and salt-leaching. As controls, porous surfaces of a PK/lithium-doped magnesium silicate blend (PKLS) and PK were fabricated using the same method. The results revealed that porosity, water absorption, and protein absorption of the porous surface of PKNLS containing macropores and nanopores were obviously enhanced compared to PKLS and PK containing macropores without nanopores. In addition, PKNLS, with both macroporostiy and nanoporosity, displayed the highest ability of apatite mineralization in simulated body liquid, indicating excellent bioactivity. In vitro responses (including adhesion, proliferation, and differentiation) of MC3T3E1 cells to PKNLS were significantly enhanced compared to PKLS and PK. In vivo implantation results showed that new bone grew into the macroporous surface of PKNLS, and the amount of new bone for PKNLS was the highest. In short, PKNLS integration with PK significantly promoted cells/bone-tissue responses and exhibited excellent osteogenesis in vivo, which might have great potential for bone repair.

Keywords:

• polyetheretherketone
• nanoporous lithium doped magnesium silicate
• porously bioactive surface
• cells responses
• osteogenesis

Acknowledgments

This study was supported by grants from National Natural Science Foundation of China (81301546 and 81501905), National Key Research and Development Program of China (No 2016YFC1100600), Natural Science Foundation of Shanghai Science and Technology Committee (114119a2800), and New Cutting-Edge Technology Project of ShenKang Hospital Development Center of Shanghai (SHDC12014124).

Disclosure

The authors report no conflicts of interest in this work.