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Abstract
Background and methods
Micronanoscale topologies play an important role in implant osteointegration and determine the success of an implant. We investigated the effect of three different implant surface topologies on osteoblast response and bone regeneration. In this study, implants with nanotubes and micropores were used, and implants with flat surfaces were used as the control group.
Results
Our in vitro studies showed that the nanostructured topologies improved the proliferation, differentiation, and development of the osteoblastic phenotype. Histological analysis further revealed that the nanotopology increased cell aggregation at the implant-tissue interfaces and enhanced bone-forming ability. Pushout testing indicated that the nanostructured topology greatly increased the bone-implant interfacial strength within 4 weeks of implantation.
Conclusion
Nanotopography may improve regeneration of bone tissue and shows promise for dental implant applications.
Acknowledgments
This study was supported by a grant from the National Natural Science Foundation of China (Grant no. 50871093), National Basic Research Program of China (973 Program, 2012CB933602), Postdoctoral Science Foundation of China (Grant no. 20110491738), and Project of Science and Technology Department of Jiangsu Province (Grant no. BK2010530).
Disclosure
The authors report no conflicts of interest in this work.