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Original Research

Tuning the surface microstructure of titanate coatings on titanium implants for enhancing bioactivity of implants

, , , , &
Pages 3887-3896 | Published online: 08 Jun 2015
 

Abstract

Biological performance of artificial implant materials is closely related to their surface characteristics, such as microtopography, and composition. Therefore, convenient fabrication of artificial implant materials with a cell-friendly surface structure and suitable composition was of great significance for current tissue engineering. In this work, titanate materials with a nanotubular structure were successfully fabricated through a simple chemical treatment. Immersion test in a simulated body fluid and in vitro cell culture were used to evaluate the biological performance of the treated samples. The results demonstrate that the titanate layer with a nanotubular structure on Ti substrates can promote the apatite-inducing ability remarkably and greatly enhance cellular responses. This highlights the potential of such titanate biomaterials with the special nanoscale structure and effective surface composition for biomedical applications such as bone implants.

Acknowledgments

The authors are grateful for the support from the National Natural Science Foundation of China under Grants 51203108, 51073113, 91027039, 51373110 and 21321062, the National Scientific Support Program of China under Grants 2012BAI07B09, the Natural Science Foundation of Jiangsu Province of China under Grants BK2011355 and BK20130313, and the Natural Science Foundation of the Jiangsu Higher Education Institutions of China under Grants 11KJB430011 and 10KJA540046.

The authors also acknowledge support from the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Qing Lan Project for Excellent Scientific and Technological Innovation Team of Jiangsu Province (2012), and Project for Jiangsu Scientific and Technological Innovation Team (2013).

Disclosure

The authors report no conflicts of interest in this work.