Nanofunctionalized zirconia and barium sulfate particles as bone cement additives

Abstract

Zirconia (ZrO₂) and barium sulfate (BaSO₄) particles were introduced into a methyl methacrylate monomer (MMA) solution with polymethyl methacrylate (PMMA) beads during polymerization to develop the following novel bone cements: bone cements with unfunctionalized ZrO₂ micron particles, bone cements with unfunctionalized ZrO₂ nanoparticles, bone cements with ZrO₂ nanoparticles functionalized with 3-(trimethoxysilyl)propyl methacrylate (TMS), bone cements with unfunctionalized BaSO₄ micron particles, bone cements with unfunctionalized BaSO₄ nanoparticles, and bone cements with BaSO₄ nanoparticles functionalized with TMS. Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO₄ ceramic particles after four hours compared to control unmodified bone cements. Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles. Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes. Finally, all bone cements containing ceramic particles possessed greater radio-opacity than unmodified bone cements. In summary, the results of this study demonstrated a positive impact on the properties of traditional bone cements for orthopedic applications with the addition of unfunctionalized and TMS functionalized ceramic nanoparticles.

Keywords:

• orthopedic
• nanotechnology
• bone cements
• osteoblasts

Acknowledgments

This research was funded by NIH grant 1R43AR056156-01, “Novel Acrylic Bone Cement Using Surface Functionalized Nanoparticles.” The authors report no conflicts in this work.