https://orcid.org/0000-0003-1851-9495
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Abstract
Background
Disorders of mineral metabolism occur in most patients with chronic kidney disease (CKD). The aim of this work was to correlate parathyroid hormone (PTH) levels with urinary magnesium excretion in patients with non-dialysis dependent CKD.
Methods
Cross-sectional study. Concentrations of creatinine, magnesium, calcium, phosphate, parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D] and alkaline phosphatase (ALP) were determined in blood samples. The assessment of urinary magnesium levels was performed by means of total daily excretion and by the excretion fraction (FEMg).
Results
The study evaluated 163 patients with a mean age of 60.7 ± 11.7 years and 51.0% were male. In the highest quartile of PTH (>89.5pg/mL), the mean levels of FEMg and ALP were higher (p<0.05). In the unadjusted regression analysis, the following variables were related to serum PTH levels: FEMg (odds ratio (OR) = 1.12; 95% confidence intervals (CI): 1.02–1.23), calcium (OR = 0.45; 95% CI: 0.22–0.90), ALP (OR = 1.02; 95% CI: 1.00–1.03) and eGFR (OR = 0.92; 95% CI: 1.00–1.03). After an adjusted analysis, only one FEMg and ALP will remain correlated with PTH.
Conclusion
In patients with non-dialysis dependent CKD, FEMg and ALP were some variables that remained associated with PTH.
Abbreviations
ALP, alkaline phosphatase; CKD, chronic kidney disease; PTH, parathyroid hormone; FEMg, magnesium excretion fraction; Mg, magnesium; MgU, urinary magnesium; CrS, serum creatinine; MgS, serum magnesium; CrU, urinary creatinine; GFR, glomerular filtration rate; eGFR, estimated glomerular filtration rate; CKD-EPI, chronic kidney disease-epidemiologic collaboration equation; BMI, body mass index; 25(OH)D, 25-hydroxyvitamin D.
Data Sharing Statement
Data not yet completed generated. All data from this study will be available as open access after publication of the articles. Any other information may be requested in writing from the chief investigator.
Ethics Approval and Consent to Participate
The study was approved by the Research Ethics Committee of the University Hospital of the Federal University of Maranhão (n. 2.727.940). All participants had provided written informed consent prior to participation in any study activities.
Author Contributions
All authors contributed to data analysis, drafting or revising the article, have agreed on the journal to which the article will be submitted, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.
Disclosure
The authors declare that they have no competing interests.