https://orcid.org/0000-0002-7981-4095
Abstract
Background
Urinary tract infection (UTI) is a common clinical problem during pregnancy that can have serious consequences for the mother and fetus. Some studies have suggested that UTI can trigger or aggravate preeclampsia. The present study aimed to investigate the association between urinary tract infection in the first trimester and the risk of preeclampsia in pregnant women referring to Bahar hospital of Shahroud.
Patients and Methods
In this case–control study, 92 pregnant women with a diagnosis of preeclampsia were selected as cases, and for comparison 92 pregnant women were selected as control. History of previous UTI in the first trimester was assessed as a risk factor. Data were analyzed using SPSS 16 software and related statistical tests such as mean and standard deviation, chi-square, and independent t-test.
Results
In this study, the mean age of the patients was 28.6 ± 6.9 years that no significant differences were found between the two groups. It was also found that 37 (40.2%) patients in the case group and 29 (31.5%) patients in the control group had a UTI which was significantly (p<0.043) higher in the case group. Also, in the multivariate regression model, UTI was significantly associated with preeclampsia (p<0.048), so that UTI increases the risk of preeclampsia (OR=1.86).
Conclusion
The results of this study showed UTI during the first trimester of pregnancy is associated with the risk of preeclampsia. Therefore, controlling and treatment of urinary infections can reduce the risk of preeclampsia in the later months.
Abbreviations
UTI, Urinary tract infection; LBW, Low Birth Weight; PE, Preeclampsia; ASB, Asymptomatic Bacteriuria; SPSS, Statistical Package for Social Science.
Data Sharing Statement
The dataset used and/or analyzed during the present study is available from the corresponding author upon reasonable request.
Ethical Standards
This study has an ethics code number (IR.SHMU.REC.1397.85) from the research deputy of Shahroud University of Medical Sciences.
Informed Consent
Informed consent was obtained from all individual participants included in the study.
Consent for Publication
All named authors have seen and agreed on the submitted version of the paper. All persons in the acknowledgments section have agreed to that inclusion.
Acknowledgment
The present study was supported by Shahroud University of Medical Sciences as a Medical Doctor (MD) Thesis. We hereby acknowledge the research deputy. Also, we would like to thank all participated patients.
Author Contributions
All authors of this article have played an active role in all aspects of the preparation of the article, including design, acquisition of data, or analysis and interpretation of data; drafting the article or revising it critically for important intellectual content; gave final approval of the version to be published; and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work.
Disclosure
The authors declared that they have no conflicts of interest.