https://orcid.org/0000-0001-8622-3480
Abstract
Breast cancer is the most common malignancy in women and the second most common cause of cancer-related death. Due to advances in the diagnosis and treatment technologies for breast cancer, patients with breast cancer are living longer than before, resulting in an increased risk of developing subsequent malignancies, among which lung cancer is the most common. This review presents the current evidence about the risk, influencing factors and prognostic factors of developing primary lung cancer after treatment for breast cancer. The aim is to help clinicians improve their understanding, diagnosis and treatment of lung cancer after breast cancer.
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Summary and Prospects
The risk of lung cancer in breast cancer patients is significantly higher than that in the general population, and this is obviously related to a number of parameters, such as smoking, radiotherapy and chemotherapy. Meanwhile, the prognosis of this group of patients might be affected by several clinicopathological parameters. However, most of the current relevant studies have only reported some clinical trends or phenomena, and we still know very little about the mechanisms by which these parameters affect the risk of subsequent primary lung cancer after treatment of breast cancer. Therefore, it is expected that additional research will focus on the mechanisms of increased risk for second primary lung cancer after treatment for breast cancer and find some possible methods to reduce the risk of subsequent lung cancer.
Ethical Statement
The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All procedures performed in studies that involved human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Written informed consent was not applicable for this type of manuscript.
Author Contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Disclosure
The authors have no conflicts of interest to declare.