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REVIEW

Innovative Surgical Approaches That Improve Individual Outcomes in Advanced Breast Cancer

, , ORCID Icon, ORCID Icon, , , , , & show all
Pages 555-560 | Received 02 Nov 2023, Accepted 25 Feb 2024, Published online: 29 Mar 2024
 

Abstract

Breast cancer is the most common cause of cancer death in women and the second cause in the general population. The incidence has increased over time. Women in developing countries often present at an advanced stage where initial surgery is not feasible. Short disease-free intervals, the number of metastatic organs and liver metastasis were consistently associated with poor overall survival. Surgery is an integral part of the therapeutic plan for locally advanced breast cancer. The integration of surgical care into the management of patients with advanced cancer has changed substantially with the use of neoadjuvant chemotherapy. Also, more recently, neoadjuvant endocrine therapy and targeted therapies offer new opportunities to downsize the tumor burden and transform the role of surgery for this population from palliation to largely curative intent. Innovative surgical approach to the primary tumor in metastatic disease may provide survival benefits and local control in some patients. Similar to systemic therapy, surgical therapy for secondary dissemination should be considered in certain cases for improved individual outcomes. Advances in reconstructive techniques have improved the quality of life of these patients.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

There is no funding to report.