Blood eosinophils and IgE levels among umbilical cord transplantation recipients with food allergies

Abstract

The use of immunosuppressive treatments and their related gastrointestinal adverse effects have been implicated in the development of food allergic responses following transplantation. There is limited information on the pathogenesis of the food allergic immune response among umbilical cord transplantation recipients. This study was conducted to identify a cohort of food allergic umbilical cord recipients in the literature. The literature was searched to systematically identify this cohort. Criteria for inclusion included umbilical cord transplantation, food allergic response, and reported laboratory data. Analysis of the laboratory data using the Pearson method revealed that there was a moderate negative correlation with a coefficient of r=−0.7016 and r²=−0.49 between peripheral eosinophilia and serum immunoglobulin E (IgE) levels. Future studies on a larger population are needed, but this study may help to elucidate possible cellular mechanisms involved in this response.

Keywords:

• GVHD
• tacrolimus
• cord blood
• stem cell

Acknowledgment

The authors would like to thank Rady Health Sciences Medical Librarian Services for their expertise and assistance in this report.

Disclosure

The authors report no conflicts of interest in this work.