Gadolinium-Based Contrast Agents Hypersensitivity: A Case Series

Abstract

Gadolinium-based contrast agents (GBCAs) are considered to be safe, although sometimes patients report a hypersensitivity reaction when undergoing magnetic resonance imaging (MRI). The mechanisms of these reactions and of the sensitization to GBCAs are still largely unknown. We describe four cases of patients who experienced immediate adverse reactions to GBCAs with a demonstrated cutaneous hypersensitivity suggesting an IgE-mediated mechanism.

Keywords:

• gadolinium-based contrast agents
• hypersensitivity
• IgE-mediated reactions

Statements of Ethics

All subjects have given their written informed consent and they have given their consent to publish the case details in this paper.

This work obtained institutional approval by Fondazione Policlinico Universitario A. Gemelli of Rome according with the Declaration of Helsinki.

Acknowledgments

The authors are responsible for the content and the writing of this paper.

Author Contributions

All authors contributed to data analysis, drafting or revising the article, have agreed on the journal to which the article will be submitted, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

The authors declare that no funding was received for the present work.