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Abstract
Purpose
The co-occurrence of adenoids and chronic cough is common in children. The goal of this research was to specify changes in cough reflex sensitivity as a result of adenoid tissue removal.
Patients and Methods
The sample group consisted of 17 children (six boys and 11 girls, aged 4–12 years, mean age 6.24 years), all of them possessing symptoms of chronic cough and adenoids, confirmed by nasal fiberoptic endoscopy. This sample group underwent cough reflex sensitivity assessment, which took place both prior to and after endoscopic adenoidectomy. The definition of the cough reflex sensitivity is the lowest capsaicin concentration that caused two (C2) or five (C5) coughs. Capsaicin aerosol in ascending concentrations (from 0.61 to 1250 µmol/L) was inhaled by a single-breath method (KoKo DigiDoser), with the addition of an inspiratory flow regulator valve (RIFR).
Results
Concentrations of capsaicin causing two (C2) and five coughs (C5) were reported. Cough sensitivity (geometric mean with 95% CI) for C2 was 31.86 (12.98–78.18) µmol/L preoperatively and 11.97 (6.16–23.26) µmol/L postoperatively (P=0.064). Cough sensitivity for C5 was 234.91 (97.19–567.77) µmol/L preoperatively and 69.13 (29.08–164.35) µmol/L postoperatively (P=0.022). The children’s pulmonary function was within the normal range.
Conclusion
In our study, adenoidectomy significantly increased cough reflex sensitivity in non-atopic children suffering from chronic cough.
Acknowledgments
This work was supported by the project of Ministry of Health of the Slovak Republic [2018/12-UKMT-8]. This publication has been produced with the support of Interreg V-A Slovenská republika–Česká republika 2014–2020, co-financed by the European Regional Development Fund; strengthening the research and development capacity of the Slovak–Czech cross-border region in the field of plasma technologies for medical use [ITMS: 304031S579].
Disclosure
The authors have no conflicts of interest to declare in this work.