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Abstract
Purpose
To review the neonatal cases with different types of minor blood group incompatible haemolytic diseases in China, and to improve the clinical understanding and management.
Materials and Methods
Seven cases from January, 1st, 2013 to December 31st, 2019 were searched out and reviewed retrospectively. All clinical data and laboratory findings were collected.
Results
There were totally seven cases enrolled including three cases of MNS, three of Diego, and one of Kidd combined with Rh, anti-RhE incompatibility. Among the seven cases, two had intrauterine transfusion, two underwent exchange transfusion, five received intravenous immune globulin, five cases developed anaemia, and three of them had transfusion. But among them, only four were found to have positive antibody screening and three were confirmed HDN with antibody types antenatally.
Conclusion
The clinical presentation is diverse. Antibody screening followed by the technique of peak systolic velocity in the fetal middle cerebral artery (MCA-PSV) helps to filter out the severe cases.
Author Contributions
Lin Mingchun: acquisition and analysis of data, drafting the article.
Liu Meixiu: data curation and analysis.
Zhang Shulian: data curation, interpretation of data.
Chen Chao: final approval of the version.
Wang Jin: design of the study, revising and final approval of the draft.
All authors contributed to the article have agreed on the journal to which the article will be submitted, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.
Disclosure
All the authors have disclosed no conflicts of interest.