Comparison of Ablation Volume Between Emprint^® and Mimapro^® Systems for Hepatocellular Carcinoma –A Preliminary Study

Abstract

Background

Microwave ablation (MWA) is a standard percutaneous local therapy for hepatocellular carcinoma (HCC). Next-generation MWA is reported to create a more spherical ablation zone than radiofrequency ablation (RFA). We compared the ablation zone and aspect ratio of two 2.45 GHz MWA ablation probes; Emprint^® (13G) and Mimapro^® (17G). We compared the ablation zone to the applied energy after MWA in patients with hepatocellular carcinoma (HCC). Furthermore, we investigated local recurrence.

Materials and Methods

We included 20 patients with HCC, with an average tumour diameter of 33.2 ± 12.2 mm, who underwent MWA using Emprint^®, and 9 patients who underwent MWA using Mimapro^® with an average tumour diameter of 31.1 ± 10.5 mm. Both groups underwent the same ablation protocol using the same power settings. The images obtained after MWA showed the treatment ablation zone and aspect ratio, which were measured and compared using three-dimensional image analysis software.

Results

The aspect ratios in the Emprint^® and Mimapro^® groups were 0.786 ± 0.105 and 0.808 ± 0.122, respectively, with no significant difference (p = 0.604). The ablation time was significantly shorter in the Mimapro^® group than in the Emprint^® group, and there was no significant difference in the frequency of popping or the ablation volume. There were no significant differences in local recurrence between the two groups.

Conclusion

There was no significant difference in the aspect ratios of the ablation diameter, and the ablation zone was almost spherical in both cases. Mimapro^® at 17G was less invasive than Emprint^® at 13G.

Keywords:

• hepatocellular carcinoma
• microwave ablation
• ablation zone

Acknowledgments

The Authors would like to thank Editage (www.editage.com) for English language editing.

Author Contributions

All authors made a significant contribution to the work, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; they took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; agreed to submit to the current journal; and agreed to be accountable for all aspects of the work.

Disclosure

The authors have no conflicts of interest to declare in relation to this study.