Postherpetic neuralgia: epidemiology, pathophysiology, and pain management pharmacology

Abstract

Herpes zoster, also known as shingles, is a distinctive clinical condition caused by the reactivation of latent varicella zoster (chickenpox) virus following an initial infection. Approximately 1 million cases of herpes zoster occur annually in the US, and one in every three people develops herpes zoster during their lifetime. Postherpetic neuralgia is a neuropathic pain syndrome characterized by pain that persists for months to years after resolution of the herpes zoster rash. It stems from damage to peripheral and central neurons that may be a byproduct of the immune/inflammatory response accompanying varicella zoster virus reactivation. Patients with postherpetic neuralgia report decreased quality of life and interference with activities of daily living. Approaches to management of postherpetic neuralgia include preventing herpes zoster through vaccination and/or antiviral treatment, and administering specific medications to treat pain. Current guidelines recommend treatment of postherpetic neuralgia in a hierarchical manner, with calcium channel α2-δ ligands (gabapentin and pregabalin), tricyclic antidepressants (amitriptyline, nortriptyline, or desipramine), or topical lidocaine patches as first-line drugs. The safety and tolerability of pharmacologic therapies for pain are important issues to consider as postherpetic neuralgia affects primarily an older population. Patients should be educated on appropriate dosing, titration if applicable, the importance of adherence to treatment for optimal effectiveness, and possible side effects. Health-care professionals play a key role in helping to ameliorate the pain caused by postherpetic neuralgia through early recognition and diligent assessment of the problem; recommending evidence-based treatments; and monitoring treatment adherence, adverse events, responses, and expectations. Nurse practitioners are especially crucial in establishing communication with patients and encouraging the initiation of appropriate pain-relieving treatments.

Keywords:

• postherpetic neuralgia
• herpes zoster
• shingles
• gabapentin
• pregabalin
• tricyclic antidepressants

Acknowledgments

This review was sponsored by Depomed, Inc. Writing and editorial assistance was provided to the authors by Iwona Bucior and Helen Nicely of Depomed, Inc.

Disclosure

Theresa Mallick-Searle is on the speakers’ bureau for Allergan, Inc., and Depomed, Inc. Brett Snodgrass is on the speakers’ bureau for Depomed, Inc., Iroko Pharmaceuticals, AstraZeneca, Purdue Pharma, and McNeil Pharma. Jeannine M Brant is on the speakers’ bureau for Genentech and Insys. The authors report no other conflicts of interest in this work.