A Single-Center Study Using IVUS to Guide Rotational Atherectomy for Chronic Renal Disease’s Calcified Coronary Artery

Abstract

Objective

To assess the effectiveness and safety of an IVUS-guided rotational atherectomy (RA) percutaneous coronary intervention (PCI) in chronic renal patients with complex coronary calcification who are at risk for contrast-related acute kidney injury (AKI).

Methods

From October 2018 to October 2021, 48 patients with chronic renal disease who were receiving PCI with RA at the General Hospital of NingXia Medical University were informed for data collection for this research. They were randomly assigned to the IVUS-guided RA group and the Standard RA group, which did not use IVUS. According to a clinical expert consensus document on rotational atherectomy in China, both PCI procedures were performed. The intravascular ultrasound (IVUS) results from the study group were used to describe the morphology of the lesion and to guide the selection of burrs, balloons, and stents. IVUS and angiography were used to evaluate the outcome in the end. IVUS-guided RA PCI and Standard RA PCI groups’ effects and results were contrasted.

Results

There were no appreciable differences in the clinical baseline characteristics between the IVUS-guided RA PCI group and the Standard RA PCI group. The average estimated glomerular filtration rate (eGFR) of two groups was (81.42 ± 20.22 vs 82.34 ± 22.19) mL/min/1.73 m². Most of them (45.8% vs 54.2%) was in stage 60–90 mL/min/1.73m². When compared to the standard RA PCI group, RA in IVUS-Guided group was more performed electively (87.5% vs 58.3%; p = 0.02). The IVUS-guided RA PCI group was associated with shorter fluoroscopy time (20.6 ± 8.4 vs 36 ± 22; p<0.01) and less contrast amount (32 ±16 vs 184 ±116mL; p<0.01) than Standard-RA group. Five patients in the Standard RA PCI group developed contrast-induced nephropathy, which was 5 times than the IVUS-guided RA PCI group (20.8% VS 4.1%; p=0.19).

Conclusion

In chronic renal patients with complex coronary calcification, an IVUS-guided RA PCI technique is effective and safe. It can also lower the volume of contrast and perhaps the incidence of contrast-related AKI.

Keywords:

• rotational atherectomy
• chronic renal disease
• contrast-associated acute kidney injury
• intravascular ultrasound

Abbreviations

PCI, percutaneous coronary intervention; AKI, acute kidney injury; CKD, chronic kidney disease; IVUS, intravascular ultrasound; RA, rotational atherectomy; TVR, target vessel revascularization.

Informed Consent Statement

The participants were fully informed about the purpose of the study and written informed consent has been obtained from them to publish this paper.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

This study was funded by the application of intravascular coronary ultrasound (IVUS) in coronary rotational atherectomy technique (No. XM2021016).