https://orcid.org/0000-0002-3294-6429
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Abstract
Aim
High expression of lytic enzymes and cytokines is related to cell proliferation in Otitis Media Chronic Suppurative (CSOM) with cholesteatoma. In addition, the process of inflammation healing and maintenance of homeostatic conditions requires Reactive Oxygen Species (ROS), which can cause significant damage to cells. To address this issue, secondary antioxidants such as Vitamins A and E are used to inhibit and neutralize the occurrence of oxidation reactions. These vitamins complement each other, with vitamin A working effectively at low concentrations of oxygen, while vitamin E functions in the opposite manner.
Purpose
This study aims to investigate the roles of vitamin A and E levels in CSOM patients with Cholesteatoma.
Patients and Methods
The study was conducted between July and December 2020, and the method used was an analytical observational approach with a case–control design. The sample population comprised 60 CSOM patients divided into 2 groups. These included those with and without cholesteatoma.
Results
The results showed that there was no significant difference between these two groups in terms of the impact of vitamin A and E levels (respectively, p = 0.626, p = 0.864).
Conclusion
Considering these results, it was discovered that vitamins A and E levels do not influence the occurrence of CSOM with or without cholesteatoma.
Abbreviation
AOM, acute otitis media; OME, otitis media with effusion; CSO, chronic suppurative otitis media; ROS, reactive oxygen species; CTA, computerized tomography; SSTS, serum separation tubes; HPL, high-performance liquid chromatography; SPSS, Statistical Product and Service Solution; BMI, body mass index; SD, standard deviation; OR, odds ratio.
Acknowledgments
The authors are grateful to everyone that contributed to the writing of this manuscript.
Disclosure
Dr. Shinta Fitri Boesoirie reports grants from Universitas Padjadjaran, during the conduct of the study; grants from Universitas Padjadjaran, outside the submitted work. No other conflict of interest has been declared.