Willingness to pay for a new drug delivery in Parkinson patients

Abstract

Objective

The Swedish reimbursement system operates a system where prices are set based on the expected value to the consumer. This value can be measured using willingness to pay (WTP).

Aim

To assess Parkinson’s disease (PD) patients’ WTP for newly developed microtablets of levodopa in combination with a drug-delivering electronic device (M/E) compared to standard treatment with levodopa in combination with the COMT (catechol-O-methyl transferase)-inhibitor entacapone (L/e).

Method

A total of 2,000 randomly included PD patients had a postal questionnaire covering demographics, disease-specific issues, views on medication and WTP in different hypothetical scenarios. The first scenario was M/E with no change in effects or side effects; the second scenario was M/E with same effect and less side effects; and the third scenario was M/E with improved effect and less side effects. These scenarios were coupled to different costs to choose from.

Results

A total of 999 patients (50%) responded, mean age of 71 years and a mean PD duration of 9 years. Of all respondents, 50% preferred M/E before L/e in scenario one with increasing preference to scenario three. The average monthly WTP among all respondents in scenario one was SEK 230 and SEK 226 in L/e, both with an almost longitudinal doubling up to scenario three. Duration of PD-related symptoms, high education, and high medication intake implied a higher WTP in all scenarios in contrast to age, sex, and extra doses of levodopa.

Conclusion

WTP for M/E increased gradually with high medication intake and education as well as with expected increased reduction of PD symptoms.

Keywords:

• Parkinson’s disease
• levodopa
• microtablets
• WTP

Acknowledgments

The authors are grateful to the patients for their collaboration in the study.

Funding for this study was provided by Sensidose AB.

Disclosure

The authors have neither financial disclosures nor conflicts of interest to declare in relation to the content of the paper.