Clinical & Neuropsychological profile in patients with Parkinson’s disease and Parkinson’s Plus syndromes: study from a tertiary care referral centre in a developing country

Abu Zafar Ansari1 Dept. of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India

Deepika Joshi1 Dept. of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, IndiaCorrespondence[email protected]

Vijay Nath Mishra1 Dept. of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India

Rameshwar Nath Chaurasia1 Dept. of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India

Shailesh Gupta2 Dept. of Cl. Neurophysiology, Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India

Baidanath Kumar1 Dept. of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India

Vijay Nandmer1 Dept. of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India

Arun Kumar,1 Dept. of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India

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Abstract

Background:

Cognitive dysfunction is an important cause of disability in Parkinson’s disease (PD) and Parkinson’s Plus syndrome (PD Plus). The development of dementia in PD has significant impact on the natural history of disease with rapid progression of disability and increased mortality. The present study aimed to evaluate the clinical and neuropsychological profile in patients with PD and PD Plus syndromes.

Methods:

Forty-one patients with a diagnosis of probable PD, and Parkinson’s Plus syndromes with minimum of fifth standard education were enrolled. They were evaluated with the UPDRS, Hoehn & Yahr staging, MMSE and AIIMS comprehensive neuropsychological battery in Hindi (adult form) using the eight lobar scales for the right and left hemisphere. Patients were then compared with age and gender matched controls.

Results:

Parkinson’s disease (85.4%) comprised

Clinical & Neuropsychological profile in patients with Parkinson’s disease and Parkinson’s Plus syndromes: study from a tertiary care referral centre in a developing country

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Clinical & Neuropsychological profile in patients with Parkinson’s disease and Parkinson’s Plus syndromes: study from a tertiary care referral centre in a developing country

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Methods:

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