Abstract:
A2a receptor (A2aR) plays an important role in the regulation of inflammatory, and immune responses. The activation of PKA-dependent and/or -independent pathways are, responsible for the downmodulation of inflammatory networks and tissue injury. Based on, promising recent studies, selective A2aR agonists are under clinical investigations for a wide, range of disorders, such as ischemia-reperfusion injury, chronic inflammation, and infectious, diseases. Nevertheless, further studies are required to improve our understanding in the ability, of A2a receptor agonists to reduce tissue damage during inflammation. Characterization of, A2aR-induced signaling pathways will be useful for the development of novel therapeutic, strategies in inflammatory/immune diseases.