Increased eating control and energy levels associated with consumption of bitter orange (p-synephrine) extract: a randomized placebo-controlled study

Abstract:

Using a placebo-controlled double-blinded 30-day protocol, 40 overweight adults were asked to consume a chocolate-flavored chew 15–30 min before their two largest meals of the day. The chews contained either a placebo or an “active” product (100 mg of a bitter orange extract, standardized to 51.5 mg p-synephrine). Subjects completed a 13-item Weight Control Support Scale (WCSS) containing eating control, energy level, and palatability subscales daily throughout the study. All 40 subjects completed the study. No adverse effects were reported in either the placebo or active groups. As compared to placebo, subjects consuming the active product reported statistically more (p≤0.001) positive responses on the WCSS as well as on each of the three subscales. This study suggests that, as compared to a placebo control, consuming a chew containing bitter orange extract (51.5 mg p-synephrine) 15–30 min before the two largest meals of the day resulted in a statistically significant greater and more positive response to eating/appetite control and a weight-control support scale.

Keywords::

• bitter orange extract
• p-synephrine
• Citrus aurantium
• appetite suppression
• energy
• safety

Acknowledgment

This study was funded by a grant from Novel Ingredients, Inc. to Integrative Health Technologies, Inc., an independent clinical research organization.

Disclosure

SJS has served as a consultant for Novel Ingredients. At no time did Novel Ingredients have access to the study data or analyses. The authors are solely responsible for the content and writing of this manuscript. The other authors report no conflicts of interest in this work.