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Neuropsychiatric Disease and Treatment Volume 15, 2019 - Issue
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Original Research

Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques

Feng-Li Deng1 Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402460, People’s Republic of China, [email protected];2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected];4 School of Public Health and Management, Chongqing Medical University, Chongqing 400016, People’s Republic of China
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Jun-Xi Pan2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected];5 The First Affiliated Hospital of Kunming Medical University, Kunming 650032, People’s Republic of China
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Peng Zheng2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected];6 Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of China
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Jin-Jun Xia2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected]
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Bang-Min Yin1 Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402460, People’s Republic of China, [email protected];2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected]
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Wei-Wei Liang1 Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402460, People’s Republic of China, [email protected];2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected]
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Yi-Fan Li2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected];6 Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of China
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Jing Wu2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected]
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Fan Xu2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected]
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Qing-Yuan Wu2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected];7 Department of Neurology, Three Gorges Central Hospital, Chongqing Medical University, Chongqing 400016, People’s Republic of China
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Chao-Hua Qu2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected]
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Wei Li2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected]
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Hai-Yang Wang2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected]
&
Peng Xie1 Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402460, People’s Republic of China, [email protected];2 Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China, [email protected];3 Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China, [email protected]Correspondence[email protected]
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Pages 1077-1088 | Published online: 01 May 2019
 
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Abstract

Purpose

Depression is a complex psychiatric disorder. Various depressive rodent models are usually constructed based on different pathogenesis hypotheses.

Materials and methods

Herein, using our previously established naturally occurring depressive (NOD) model in a non-human primate (cynomolgus monkey, Macaca fascularis), we performed metabolomics analysis of cerebrospinal fluid (CSF) from NOD female macaques (N=10) and age-and gender-matched healthy controls (HCs) (N=12). Multivariate statistical analysis was used to identify the differentially expressed metabolites between the two groups. Ingenuity Pathways Analysis and MetaboAnalyst were applied for predicted pathways and biological functions analysis.

Results

Totally, 37 metabolites responsible for discriminating the two groups were identified. The NOD macaques were mainly characterized by perturbations of fatty acid biosynthesis, ABC transport system, and amino acid metabolism (eg, aspartate, glycine, serine, and threonine metabolism). Interestingly, we found that eight altered CSF metabolites belonging to short-chain fatty acids and amino acids were also observed in the serum of NOD macaques (N=13 per group).

Conclusion

Our findings suggest that peripheral and central short-chain fatty acids and amino acids are implicated in the onset of depression.

Supplementary material

Table S1 The included behaviors of 12 behavior categories

Acknowledgments

This work was supported by the National Key R&D Program of China (Grant Nos 2017YFA0505700 and 2016YFC1307200), the National Natural Science Foundation of China (Grant Nos 81701360 and 81701361), Chongqing Post-Doctoral Science Foundation Projects (Grant No Xm2017026), and Chongqing Science & Technology Commission (cxth2017jcyjA0207).

Disclosure

The authors report no conflicts of interest in this work.

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