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Abstract
Purpose
Genetic factors play a vital role in intracranial aneurysm (IA) onset and development. Studying the relationship between IA and the Sox17 polymorphisms in diverse populations is essential for establishing credibility.
Patients and methods
We collected blood samples derived from a total of 596 sporadic IA patients and 600 individual controls in several medical institutes in China. We used the Sequenom MassArray system for single nucleotide polymorphisms (SNPs) genotyping after DNA extraction. The SNPs data was tested and analyzed in PLINK (version 1.9). Multiple-testing was performed in PLINK to make the statistics more rigorous and accurate.
Results
We found that the allelic G of rs1072737 (OR=1.303, genomic-control corrected P-value =0.001032) is a risk allele, while the allelic G of rs9298506 (OR=0.7253, genomic-control corrected P-value =0.01559) is a protective allele in Chinese Han people.
Conclusion
The allelic G of rs1072737 is a risk factor for IA, while the allelic G of rs9298506 serves as a protective factor for IA in Chinese Han people.
Acknowledgments
The authors thank BioMiao Biotechnology (Beijing) Co. Ltd for providing SNP sequencing and bioinformatics analysis services. The authors appreciate the Chinese Multicenter Cerebral Aneurysm Database (CMAD), which contributed clinical data and blood samples to this study. The authors thank the National Natural Science Foundation of China (81571144) and (81501073), and the Natural Science Foundation of Tianjin City (16JCZDJC35700) and (15ZXLCSY00060) for supporting this work.
Disclosure
The authors report no conflicts of interest in this work.