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Abstract
Objective
The aim of this study was to validate the reliability of the Chinese version of Addenbrooke’s Cognitive Examination III (ACE-III) for detecting mild cognitive impairment. Furthermore, the present study compares the diagnostic accuracy of ACE-III with that of Montreal Cognitive Assessment (MoCA).
Methods
One hundred and twenty patients with MCI and 136 healthy controls were included in the study. All patients were evaluated by the Chinese version of ACE-III, MoCA and MMSE.
Results
Subjects in the control group showed better performance in ACE-III total score and its subdomain scores than those in the MCI group. There was a significantly positive correlation between ACE-III total score and MoCA score. Meanwhile, there was also a significantly positive correlation between ACE-III total score and MMSE score. For ACE-III total score, a cut-off point of 85 yielded a sensitivity of 97.3% and a specificity of 90.7%. The AUC for ACE-III total score was 0.978. For MoCA, a cut-off point of 23 yielded a sensitivity of 86.5% and a specificity of 97.7%. The AUC for MoCA was 0.961. There were no significant differences in diagnostic accuracy between ACE-III and MoCA.
Conclusion
The present findings support that both ACE-III and MoCA are useful for detecting MCI in early stages.
Acknowledgments
The study was funded by National Natural Science Foundation of China (81500916), Youth Medical Talents Program of “Science and Education Strong Health Project” of Jiangsu Province (QNRC2016079), Medical Innovation Team Program of “Science and Education Strong Health Project” of Jiangsu Province (CXTDA2017030) and Cardre’s Health Care Project of Jiangsu Province (BJ18027).
Author contributions
BRW, HFZ, YDZ, and JQS participated in study design and data interpretation. YDZ and JQS played key roles in the development of all components of the manuscript. BRW and JQS drafted the manuscript. HFZ and YDZ revised the manuscript. CX and YS participated in data acquisition, data interpretation, and manuscript drafting. All authors gave final approval of the version to be published. All authors agreed to be accountable for all aspects of the work.
Disclosure
Dr Bian-Rong Wang reports grants from Cardre’s Health Care Project of Jiangsu Province (BJ18027), during the conduct of the study. Dr Ying-Dong Zhang reports grants from Medical Innovation Team Program of “Science and Education Strong Health Project” of Jiangsu Province (CXTDA2017030), during the conduct of the study. Dr Jian-Quan Shi reports grants from National Natural Science Foundation of China (81500916), Youth Medical Talents Program of “Science and Education Strong Health Project” of Jiangsu Province (QNRC2016079) and Medical Innovation Team Program of “Science and Education Strong Health Project” of Jiangsu Province (CXTDA2017030), during the conduct of the study. The authors report no other conflicts of interest in this work.