Effects of once-daily extended release quetiapine fumarate on patient-reported outcomes in patients with generalized anxiety disorder

Abstract

Background

We evaluated the effects of once-daily extended-release quetiapine fumarate (quetiapine XR) on patient-reported outcomes in generalized anxiety disorder (GAD).

Methods

This is a report of a pooled analysis from three acute 8-week, randomized, placebocontrolled, fixed-dose (50, 150, 300 mg/day) studies and a 52-week maintenance flexible dose (50–300 mg/day) study of quetiapine XR monotherapy in patients with GAD. Quality of Life Enjoyment and Satisfaction Questionnaire Short Form (Q-LES-Q-SF) percent maximum total scores (items 1–14), item 15 (“satisfaction with medication”), item 16 (“overall life satisfaction”), and Pittsburgh Sleep Quality Index (PSQI) global scores are reported. Sheehan Disability Scale (SDS) total scores were also assessed (maintenance study only).

Results

The acute studies showed significant improvements at week 8 in Q-LES-Q-SF percent maximum total score with quetiapine XR 150 mg/day (P < 0.001) and item 16 with quetiapine XR 50 (P < 0.05) and 150 mg/day (P < 0.001) versus placebo; PSQI global scores significantly improved with quetiapine XR 50, 150, and 300 mg/day versus placebo (P < 0.001). The maintenance study showed significant benefits versus placebo with quetiapine XR 50–300 mg/day in Q-LES-Q-SF percent total score, item 15 and item 16 scores, PSQI global score, and SDS total score.

Conclusion

Quetiapine XR 150 mg/day (acute studies) and 50–300 mg/day (maintenance study) improved quality of life, overall functioning, and sleep quality in patients with GAD.

Keywords:

• atypical antipsychotic
• anxiety disorders
• quality of life
• sleep quality
• functioning
• randomized studies

Disclosure

These studies (Titanium, D1448C00009; Gold, D1448C00010; Silver, D1448C00011; Platinum, D1448C00012) were funded by AstraZeneca Pharmaceuticals. Sarah Lewis, from Complete Medical Communications, provided medical writing support funded by AstraZeneca. JE is an employee of the New York State Department of Mental Health and has received research support from the Department as well as the US National Institute of Mental Health, Cyberonics, and Pfizer. She has served as a consultant or advisory board member to AstraZeneca, Bayer, Cyberonics, Otsuka, Pfizer, and Wyeth-Ayerst. She is the author of the Quality of Life Enjoyment and Satisfaction Questionnaire. Henrik Svedsäter is a former employee of AstraZeneca. Julie Locklear is a current employee of AstraZeneca.