Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)

Abstract

Purpose

To assess the effects of 0.5% and 1% cyclopentolate on the main parameters of the anterior segment (central corneal thickness (CCT), anterior chamber angle (ACA), depth (ACD) and volume (ACV)) in low/moderate myopia and hyperopia along with the effect on IOP.

Patients and Methods

Both eyes of 30 subjects (15 myopic and 15 hyperopic) with mean age±standard deviation of 21.4±3.6 years were enrolled. Each participant was administered two drops of cyclopentolate 1% in the right eye and two drops of cyclopentolate 0.5% in the left eye, 15 minutes apart. All participants underwent intraocular pressure (IOP) measurement using noncontact tonometry, and anterior chamber parameter measurement using Pentacam.

Results

Following the use of 0.5% and 1% cyclopentolate among the hyperopic group, there was a statistically significant increase in ACD for 1% (pre 2.762±0.28 mm and post 2.89±0.25 mm) and 0.5% (pre 2.71±0.28 and post 2.86±0.27 mm) and ACV for 1% (pre 141.40±20.59 mm³ and post 154.35±19.69 mm³) and 0.5% (pre 137.40±20.48 mm³ and post 152.93±20.50 mm³). In contrast, ACA decreased with both doses 1% and 0.5%, but was not statistically significant (p for both >0.05%). With 0.5% and 1% cyclopentolate among the myopia group, there was a significant increase in ACD following cyclopentolate 1% (pre 3.18±0.22 mm and post 3.25±0.21 mm) and 0.5% (pre 3.200±0.22 mm and post 3.26±0.05 mm), p˂0.05. The ACV was significantly increased following 1% cyclopentolate, p˂0.001. The ACA showed a statistically significant decrease following cyclopentolate 1%, P=0.01, but not a significant decrease after cyclopentolate 0.5%, P=0.170. There was a significant increase in the IOP after 1%, p˂0.001, while a decrease with 0.5%, p=0.008.

Conclusion

A topical dosage of cyclopentolate 1% showed significant changes in ACA and ACV among the hyperopia and myopic groups compared to 0.5%. Therefore, it is important to consider the use of a 0.5% cyclopentolate dosage to minimize changes to anterior chamber parameters.

Keywords:

• cycloplegic
• anterior chamber angle
• anterior chamber volume depth
• central corneal thickness

Acknowledgments

We are grateful to the staff and students of the Department of Optometry, Qassim University who helped us in the process of data collection. We extend our sincere thanks to Abdulmohsen Mubarak Alharbi and Abdulelah Abdulrahman Alshumaym for their help in data collection. We would also like to thank all the students and teachers who participated in this study.

Author Contributions

Waleed M. Alghamdi: Conception of study, study design, data collection, approval of final manuscript; Saif H Alrasheed: Conception of study, study design, data analysis, drafting of manuscript; Vishakh Nair: Conception of study, study design, data collection, drafting of manuscript; Muhammed S. Alluwimi: Conception of study, data analysis, editing of manuscript. All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; agreed to submit to the current journal; gave final approval of the version to be published; and agree to be accountable for all aspects of the work.

Disclosure

The authors report no conflicts of interest for this work and declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article.