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Original Research

Ocular pain and discomfort after advanced surface ablation: an ignored complaint

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Pages 1625-1632 | Published online: 04 Sep 2015

Abstract

Purpose

Laser vision correction is one of the most commonly performed elective surgical procedures in ophthalmology. Generally, discomfort besides pain (photophobia, burning sensation, tearing, and foreign body sensation) after these procedures is not taken into consideration in the clinical practice. The objective is to provide data on these symptoms and their relevance after advanced surface ablation (ASA).

Methods

Single-center survey study based on a structured questionnaire relative to the patients’ perceived symptoms after ASA. Inclusion criteria were: ≥18 years old, no ocular disease, with myopia (0.75 to 9 D) or hyperopia (0.25 to 5 D) with or without astigmatism, receiving ASA on at least one eye. All procedures were performed by the same surgeon. A descriptive analysis was performed.

Results

Seventy-three consecutive patients (34 men and 39 women) were included in the study. The median (range) of age was 33 (19–64) years. Sixty-nine patients had surgery done on both eyes. Postoperative pain was the most frequent comorbidity (97% [95% confidence interval {CI}: 90–100]) with a median (range) of intensity (verbal numerical rating scale) score of 7 (2–10). Photophobia: 85% (95% CI: 75–92); burning sensation: 62% (95% CI: 50–73); tearing: 59% (95% CI: 47–70); and foreign body sensation: 48% (95% CI: 36–60) were also prevalent postoperative symptoms. Pain during ASA was reported for 44% (95% CI: 32–56) of patients.

Conclusion

Comorbidities such as pain, photophobia, burning sensation, tearing, and foreign body sensation are prevalent after ASA procedure. Postoperative pain should be taken into consideration due to its prevalence and intensity. A new and more efficient postoperative analgesic protocol should be established.

Introduction

Advanced surface ablation (ASA) and photorefractive keratectomy (PRK) and its variations are currently common procedures to correct some refractive errors safely and effectively.Citation1 Postoperative pain management is one of the drawbacks of these procedures, which remains an unresolved issue.Citation2,Citation3

Current studies, focused on finding corneal pain pathways and alternatives to control it, confirm the relevance of this topic.Citation4 ASA and the subsequent corneal epithelial defect leave numerous highly sensitive nerve terminals exposed. The stimulation of these terminals results in intense pain and neurogenic inflammation.Citation5 With the aim of controlling these effects, researchers have tried some approaches, which are not fully satisfactory. In this vein, although PRK causes less postoperative pain than ASA, severe pain is present in practically all patients after PRK procedure,Citation6 which may limit its acceptance. Despite new intrastromal techniques with femtosecond laser which seemed to have reduced this problem, this technique has not been popularized yet, probably due to the worldwide recession environment.Citation2,Citation3 The mechanism of pain after refractive surgery is multifactorial and its understanding seems crucial for an appropriate management.Citation7 Recent papers about pain management in postoperative refractive surgery show that it remains an unsolved issue.Citation8,Citation9

The potential target for pain relief has numerous approaches; for example, a bandage contact lens (BCL) is effective in improving postoperative comfort by preventing lid movements over the abraded cornea and reducing stimulation of the nerve fibers sensitive to mechanical stimulation.Citation10 However, wearing a BCL is not enough to eliminate pain in most patients.Citation11 Topical nonsteroidal anti-inflammatory drugs (NSAIDs) help reduce pain following PRK but could interfere with the healing process.Citation12 Furthermore, the direct application of cold balanced saline solution (BSS) on the cornea is believed to alleviate the pain caused by exposed nerve endings.Citation12

In previously published studies on the evaluation of pain after refractive surgery, some limitations have been observed. One of them is the time of follow-up. In order to make a good assessment of postoperative pain in refractive surgery, a minimum of 72-hour evaluation time is necessary.Citation11,Citation12 Studies evaluating pain over a 24-hour postoperative period are considered insufficient.Citation9

Although pain is one of the most important limitations of postoperative refractive surgery, there are other symptoms, generically named discomfort, that have been observed in the majority of patients. These symptoms are another important limitation of refractive surgery,Citation13 and have received little attention. Therefore, the purpose of this study is to provide data on the patient-referred ocular sensations in terms of postoperative pain, during and after ASA, evaluated over 1 week, using a numerical rating scale (NRS) and paying attention to other relevant symptoms such as photophobia, burning, tearing, and foreign body sensation. These data will help refractive surgeons to improve their clinical practices.

Patients and methods

Study design

Single-center survey study based on the structured questionnaire relative to the patients’ perceived symptoms after ASA. The ethical committee of the University of Valladolid reviewed and approved the study protocol. The study complies with the updated Declaration of Helsinki and the Spanish biomedical research regulatory requirements. All subjects provided their verbal informed consent before their participation in the study.

Study population

Patients included in this study had to fulfil the following eligibility criteria: ≥18 years old, with no ocular disease other than ametropia, with myopia (0.75 to 9 D) or hyperopia (0.25 to 5 D) with or without astigmatism, receiving ASA on at least one eye. All patients were operated on by the same surgeon (MJM). Patients, who fulfilled the inclusion criteria, were identified, and contacted via phone by the same interviewer (EMS). The study was explained to each patient, and before starting the interview, verbal consent was requested.

ASA procedure

ASA included topical application of one drop of 5% lidocaine twice at a 10-minute interval, 20 minutes before entering the operating theater. All patients received 0.5 mg alprazolam (Trankimazin®, Pfizer, Inc., New York, NY, USA), 30 minutes before surgery. Ethyl alcohol solution (17%) was placed on the cornea within an 8.5 mm solution cone and left in place for 30 seconds. Then, a Merocel sponge (Medtronic Xomed Ophthalmics, Inc. Jacksonville, FL, USA) was placed to absorb the excess ethanol. After that, the corneal surface was rinsed with a topical cold BSS. The epithelium was removed with a blunt spatula. This manoeuvre was followed by stromal ablation using excimer laser MEL 70 G (Carl Zeiss Meditec AG, Jena, Germany). This excimer laser incorporates a tracking eye system. The diameter of the treated area was always 6 mm. Then a drop of 0.3% ofloxacin (Exocin®, Allergan, Inc., Irvine, CA, USA) and a drop of 0.18% sodium hyaluronate (Vismed®, Thea Laboratories, SA, Barcelona, Spain) were applied. A therapeutic contact lens (Acuvue Oasis®, Johnson & Johnson, New Brunswick, NJ, USA) kept at 4°C was placed onto the cornea at the end of the procedure. Immediately after surgery, patients received a cold patch for 15 minutes. Patients were given alprazolam 0.5 mg for the first 2 postoperative nights and all other eye-drops (ofloxacin QID, dexamethasone TID, and artificial tears QID) that had to be kept at 4°C (fridge temperature). Initially, painkillers were not prescribed unless pain was deemed unbearable. In this case, the patient was given a protocol to use a rescue medication.

Questionnaire: pain intensity and other symptoms after ASA procedure

An ad hoc questionnaire was created to record the patients’ perceived symptoms after ASA (). The questionnaire consists of five parts or domains: 1) cognitive orientation, 2) pain perception, 3) other symptoms (foreign body, tearing, photophobia, burning), 4) pain treatment prescribed, and 5) miscellanea. Furthermore, pain intensity was evaluated by means of an NRS, ie, 0- no pain and 10- the worst imaginable pain.Citation14

Figure 1 Ad hoc questionnaire used in the telephonic interview.

Figure 1 Ad hoc questionnaire used in the telephonic interview.

Statistical analysis

This study was designed assuming that 95% (internal data) of the participants would present pain after ASA procedure. It was calculated that a representative sample for a survey study should include 73 subjects, based on the normal approximation with a range of ±2.5% for a two-sided 95% confidence interval (CI).

Baseline characteristics were summarized with standard descriptive statistics and a descriptive analysis was carried out. The prevalence of symptoms after ASA procedure was estimated and its 95% CI was calculated. The Spearman’s correlation coefficient was used to assess the relation between the subjective feeling of pain and age and amount of ablation, and between discomfort and age and amount of ablation. Data analysis was carried out using SPSS version 15.0 statistical software (SPSS Inc., Chicago, IL, USA) and StatXact-8 (Cytel Inc., Cambridge, MA, USA).

Results

Patients’ characteristics

A total of 73 consecutive patients (34 men and 39 women) were included. All contacted patients agreed to participate in the interview. The median (range) of age was 33 (19–64) years, and 69 (95%) patients received surgery on both eyes.

Pain after ASA procedure

Pain intensity and other symptoms are shown in : 51% of the patients reported pain during surgery; 8% of the patients reported more pain during the first eye surgery, 19% during the second eye surgery, and 73% of the patients presented the same pain in both eyes. Ninety-seven percent of the patients reported pain (score equal or higher than 2) during the postoperative period. Only two women did not feel pain in the postoperative period. The median (range) score of the worst pain intensity was 7 (0–10) (mean [± SD]: 6.3 [±2.5]), and 49 patients (67%) had severe pain (6 or higher). It is noteworthy that 38 patients (52%) reported a pain intensity higher than 7. The median (range) duration of the pain was 3 days (range: 1–7). Twenty-nine (40%) patients required analgesic treatment in the postoperative period, out of which eleven patients (15%; 95% CI: 8–25) chose analgesic rescue medication and 18 patients (25%) used another painkiller (metamizol or ibuprofen), which was not included in the protocol.

Table 1 Pain intensities (during ASA procedure and postoperative period), photophobia, burning, tearing, and foreign body sensation results

Regarding the patients’ impression about the prescribed treatment for pain, 67 patients (92%; 95% CI: 83–97) scored it as “satisfactory” or “very satisfactory”. The remaining six patients marked “slightly satisfactory”.

Other symptoms after ASA procedure

Regarding other postoperative symptoms such as photophobia, burning, tearing, and foreign body sensation, results are shown in . After pain, the most frequent (85%) and most intense symptom was photophobia with a mean (± SD) intensity score of 8.0 (±2.2). Burning sensation was also a very prevalent symptom (62%) with a mean (± SD) intensity score of 6.8 (±2.5). It is relevant to mention that 36 patients (80%) had values higher than 5 for burning sensation.

The mean (± SD) intensity score for tearing was 7.2 (±2.5). A high percentage of patients (63%) scored higher than 7 for tearing intensity. The less common symptom was foreign body sensation with a mean (± SD) intensity score of 6.1 (±2.5); 67% of patients scored equal or higher than 5 for this symptom.

The survey included a question to identify other complaints, referred to by the patients: inability to open eyes (8 [11%] patients); itching or sharp ocular pain (5 [7%] patients); swollen eyelids (3 [4%] patients); dryness (4 [5%] patients); and migraines (3 [4%] patients).

No relationship was found between feeling of pain and age and amount of ablation, and between discomfort and age and amount of ablation.

Pain control (cold eye-drop and anxiolytics)

In this study, chilled BSS was used during surgery and it was recommended that the patient used cold eye-drops to increase analgesia. A protocol of painkillers was not included as a standard in the postoperative medication.Citation15,Citation16 Painkillers were used on demand as a rescue medication by the patients themselves. The proportion of patients reporting additional need for analgesia was 40% (29 patients), but only eleven of them used the recommended rescue medication. The rest of the patients (25%) used painkillers not included in the protocol.

Discussion

ASA and PRK result in a complex cascade of events that trigger sensory afferent fibers in the cornea, producing various degrees of pain.Citation4 It is admitted that postoperative pain resulting from corneal epithelial debridement remains a significant limitation to the acceptance and usefulness of these procedures.Citation5,Citation17,Citation18 In PRK, epithelial debridement is performed;Citation19 thus techniques to preserve the epithelium are used in an attempt to decrease postoperative pain.Citation20 But the effect of removal of epithelial flap versus preservation of the flap on postoperative pain is unclear.Citation4 In a study, Epi-LASIK versus off-flap Epi-LASIK were compared, and subjective pain scores were lower at 2 hours follow-up in the off-flap Epi-LASIK group, but not at 4, 6, 8, 10 or 24-hour intervals.Citation21 In other study, postoperative pain was similar between Epi-LASIK and off-flap Epi-LASIK groups.Citation22 Our results are in line with previous studies, in that severe pain was present in practically all patients after ASA procedure,Citation23 and the time course of pain was as expected.Citation24 Pain begins within 1 hour. Its intensity increases until 4 hours after the surgical procedure, peaking at approximately 24 hours postoperation,Citation25 and subsides within 72 hours after surgery, when reepithelialization is complete.Citation24,Citation26 Therefore, the results of this study provide evidence that the peak of pain is at 24 hours and median duration of pain is 3 days. In consequence, a complete postoperative pain assessment after ASA should be performed for at least this number of hours.

Management of acute postoperative pain is a challenge for any surgery and acute ophthalmologic postoperative pain is not an exception. Likewise, intraoperative pain is also important. Moreover, data available on the perception of pain during ASA procedure and its frequency are scarce.Citation27 Our study evaluated intra-operatory pain finding that half the patients notice pain during surgery. Another novelty in the outcome of this study is that 73% of these patients referred to the same pain in both eyes and only 19% reported more pain in the second eye. There are studies reporting the subjectivity of patients’ pain after first eye cataract surgery versus second eye,Citation28 but we have not found any regarding ASA. Another important result is 25% of patients used painkillers outside the protocol, acting by themselves instead of using the recommended rescue medication. This lack of compliance was attributed by the patients to the potential side effects related to the prescribed medication.

It is noteworthy that patients who have undergone refractive surgery are generally young and healthy, so they may be considered as “healthy volunteers”. Besides, they have been previously informed about the transience of the postoperative discomfort and pain. Therefore, it is fair to say that the benefit of the operation prevails over other negative features. That is to say, the emotional aspect tends to minimize the postoperative symptoms.Citation8 Our study did not allow for predicting what type of patients might be at increased risk for pain intolerance. In fact, this could be another area of ocular pain research. To use a questionnaire or other kind of noninvasive test at the time of deciding whether to perform ASA, PRK or another refractive procedure could help the ophthalmologist in the control of postoperative pain. Consequently, this may help minimize the number of patients with severe postoperative pain and discomfort.

A crucial issue dealing with pain is how to measure it in clinical practice. In our study, a verbal NRS was used because the study was conducted via telephone interview. Different types of scales have been developed to evaluate pain, including visual analog scale (VAS) and various categorical scales using faces, numbers, or verbal categorical descriptors,Citation29 although, none has been specifically developed and validated for ophthalmic pain.Citation17 The majority of previous investigators have used general pain scales to measure pain after ophthalmic procedures.Citation23 The most recommended methods for the assessment of pain intensity are NRS, verbal rating scale (VRS), or VAS, because all of them provide sufficient power to describe pain intensity.Citation30 Most of the reviewed papers used versions of scales according to current recommendations, primarily NRS-11, VRS up to seven categories, and VAS-100 mm.Citation31 NRS and VRS, which are validated scales, showed a high concordance between them and are equally sensitive in assessing acute pain after surgery.Citation27 In a review, these three scales for the assessment of postoperative pain intensity in adults were evaluated.Citation30 This study concluded with a novel idea. The most important choice is not the type of scale, but the conditions related to its use, such as a standardized choice of anchor descriptor, methods of administration, and time frame, among others.Citation30 They believed that all of these areas can be improved by an international consensus process following the medicine-based evidence rules, which should include improving and standardizing the use of NRS.Citation30 The validity of the VAS and NRS for pain could be extended by using other clinically relevant descriptors of pain such as the proportion of patients reporting need for analgesia.Citation32 In our study where 97% of patients reported pain in the postoperative period, only 40% of patients mentioned that they required analgesics.

Another important limitation of refractive surgery is the existence of postoperative discomfort.Citation26 With this respect, a study stood out because the author distinguished between pain and discomfort, explaining that discomfort is a group of symptoms characterized by photophobia, burning, tearing, and foreign body sensation, and all of them were individually evaluated.Citation13 Most of the studies only evaluate some of these symptoms, with photophobia being the most frequent.Citation5 In a recent study, Citation13 most patients reported discomfort with a score of 8 or 9 on a 10-point pain scale, while in our study, photophobia was the only symptom with a score of 8. After postoperative pain, photophobia was the prevalent symptom present in 85% of our patients. These results are in line with other reports.Citation5,Citation24,Citation25

On the other hand, factors such as age and amount of ablation were not associated with pain and discomfort after ASA. Similar findings have been reported.Citation13 Although, it is worth mentioning that in our study, all age groups are not represented since the patients included are very young. Therefore, this study suggests that a new pain management strategy is necessary at least during the 3 days postoperative ASA. Similarly, there are other symptoms related to ocular discomfort which should call our attention to lead us toward better postoperative care.

Postoperative pain and discomfort after refractive surgery still is not well controlled. Recent studies have reviewed pain management strategies after PRK.Citation4,Citation33Citation35 These strategies include the use of cold BSS during the procedure,Citation34 and the postoperative placement of extended-wear BCLs until reepithelialization occurs.Citation35 Topical NSAIDs are often used to manage pain and discomfort following refractive surgery.Citation4 Common ocular adverse events of topical NSAIDs include transient burning, stinging, and conjunctival hyperemia, and the most serious adverse events are superficial punctate keratitis, corneal infiltrates, epithelial defects, and corneal melts.Citation33 Moreover, there is also concern that topical NSAIDs may lead to delayed epithelial healing. This was the main reason why these topical drugs were excluded from our ASA postoperative clinical protocol. Instead, oral medications approved for neuropathic pain, such as gabapentin and pregabalin, are adjunctive agents that help minimize the use of topical medication.Citation36 Despite the fact that oral NSAIDs are considered excellent analgesics in many acute pain settings, they have not been specifically studied for post-PRK pain.Citation37 Oral analgesics, such as opiates, may be used for moderate-to-severe pain after PRK because opioid receptors present in the cornea respond to them.Citation4 With the advent of new methods of analgesia targeting specific corneal sensory afferent nociceptors, discomfort can be minimized with less impact on corneal healing.Citation4 These concepts might be important to evaluate in future studies looking at optimization of pain management.

There are several limitations to this study, which should be considered before drawing any conclusions. The study design (survey study), the use of a telephone questionnaire instead of a personal interview, and the type of population analyzed (from a single geographical site and operated on by a single surgeon in the center of reference) might underestimate or overestimate the generalization of the results beyond the population and conditions studied. Likewise, since the patients were directly asked about pain, photophobia, burning, tearing, and foreign body sensation, this kind of questioning might overestimate the results. Nevertheless, this type of procedure (telephone questionnaire) in a survey study is considered reliable and valid and has been used for evaluating acute eventsCitation38,Citation39 and chronic pain.Citation40 On the other hand, one of the problems related to telephone surveys is their duration, which could influence the quality of the answer. This study was done in a 10-minute time period. In spite of these limitations, our study provides new evidences on the comorbidities related to the PRK procedure.

Conclusion

In conclusion, our results suggest that several comorbidities such as pain, photophobia, burning, tearing, and foreign body sensation are prevalent after an ASA procedure. Among them, postoperative pain should be taken into consideration because of its prevalence and intensity. These results justify additional research to get a more efficient postoperative analgesic protocol after ophthalmologic surgical procedures.

Disclosure

The authors report no conflicts of interest in this work.

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