Monitoring and Management of the Patient with Stargardt Disease

Abstract

Stargardt disease (STGD1) represents one of the major common causes of inherited irreversible visual loss. Due to its high phenotypic and genotypic heterogeneity, STGD1 is a complex disease to understand. Non-invasive imaging, biochemical, and genetic advances have led to substantial improvements in unveiling the disease processes and novel promising therapeutic landscapes have been proposed. This review recapitulates the modalities for monitoring patients with STGD1 and the therapeutic options currently under investigation for the different stages of the disease.

Keywords:

• Stargardt disease
• inherited retinal dystrophy
• multimodal imaging
• optical coherence tomography
• gene therapy

Disclosure

FB is a consultant for: Alcon (Fort Worth,Texas,USA), Alimera Sciences (Alpharetta, Georgia, USA), Allergan Inc (Irvine, California,USA), Farmila-Thea (Clermont-Ferrand, France), Bayer Shering-Pharma (Berlin, Germany), Bausch and Lomb (Rochester, New York, USA), Genentech (San Francisco, California, USA), Hoffmann-La-Roche (Basel, Switzerland), NovagaliPharma (Évry, France), Novartis (Basel, Switzerland), Sanofi-Aventis (Paris, France), Thrombogenics (Heverlee,Belgium), Zeiss (Dublin, USA). He also reports personal fees from Allergan Inc, Bayer, Boehringer Ingelheim, Fidia Sooft, Hofmann La Roche, Novartis, NTC Pharma, SIFI, Thrombogenics, and Zeiss, outside the submitted work. The authors report no other conflicts of interest in this work.