The Effect of Home-Based Dichoptic Therapy on Young Adults with Non-Strabismic Anisometropic Amblyopia on Stereo Acuity

Abstract

Aim

To evaluate the effect of home-based dichoptic visual therapy using anaglyphic red-green filters on the stereo acuity in a sample of young adults with non-strabismic anisometropic amblyopia.

Methods

The study was observational and cross-sectional in design. Two groups (experimental vs control) were sourced using purposive sampling of young adults with non-strabismic amblyopia (experimental group) in comparison to an age-match control group without amblyopia. For the purpose of refractive adaptation, all participants in both groups were asked to wear their spectacle correction constantly for at least 16 weeks prior to exposure to home-based dichoptic therapy. Stereo acuity measurements using the Stereo Fly test were obtained before and after 40 hours exposure to home-based dichoptic therapy. The changes in stereo acuity post eight weeks (40 hours) training from baseline measurements was obtained. The difference in medians between the experimental and control groups using the Mann–Whitney U-test was measured with significance set at P value of <0.05.

Results

A total of 38 young adults (19 males, 19 females) with a mean age of 24.05 ± 5.66 years were enrolled in this study. Nineteen anisometropic amblyopes comprised the experimental group, fifteen of which were classified as moderate amblyopia (6/12-6/36) and 19 non-amblyopes comprised the control group. Home-based dichoptic therapy used on the experimental group after 8 weeks showed a significant improvement in stereo-acuity with a mean improvement of 345.26 ± 184.85 sec arc⁻¹ [IQR:260;600; p<0.001] when compared to the control group.

Conclusion

Home-based dichoptic therapy improved stereo-acuity in non-strabismic anisometropic amblyopes (moderate) in young adults. Thus suggesting that binocularity can improve in anisometropic adult amblyopes with a treatment modality that may be a convenient option better suit the demanding lifestyle of economically active adults who may not be able to comply with clinic-based therapy.

Keywords:

• adult amblyopia
• stereo acuity
• anisometropia
• binocular vision
• dichoptic therapy

Ethics and Consent

Biomedical Research Ethics Committee (BREC) BREC Ref No: BE704/18.

Affiliation: University of KwaZulu-Natal (UKZN).

A written consent to participate was obtained from all participants of the study.

Acknowledgments

University of KwaZulu-Natal (UKZN), Developing Research Innovation, Localization and Leadership in South Africa (DRILL) fellow. DRILL, is a NIH D43 grant (D43TW010131) awarded to UKZN in 2015 to support a research training and induction programme for early career academics. The content is solely the responsibility of the authors and does not necessarily represent the official views of DRILL and the National Institutes of Health.

Author Contributions

Both authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

The authors report no conflicts of interest in relation to this work.