Cabazitaxel in the treatment of metastatic castration-resistant prostate cancer: patient selection and special considerations

Abstract

Cabazitaxel is an effective chemotherapeutic agent used in the treatment of metastatic castration-resistant prostate cancer (mCRPC) refractory to docetaxel. With the advent of new antiandrogen therapies, immune-based treatments, and radioactive-targeted therapy, there are now multiple effective and approved agents for this disease state. The optimal sequencing of these agents is unclear as there are no large-scale head-to-head comparisons. Clinicians must familiarize themselves with the most recent studies as well as drug toxicities to determine the best treatment option for their patients. In this review, we focus on the development of cabazitaxel for mCRPC, evaluate its efficacy, and highlight key strategies for toxicity management. Additionally, we summarize the studies that address cabazitaxel treatment sequencing and optimal dosing schedule.

Keywords:

• sequencing
• clinical trials
• docetaxel
• abiraterone
• enzalutamide
• biomarkers

Disclosure

JHC is a consultant for Genentech, Clovis Oncology, and Foundation Medicine and reports research support from Sanofi and medical writing services from Genentech. The authors report no other conflicts of interest in this work.