The relationship between IGF2BP2 and PPARG polymorphisms and susceptibility to esophageal squamous-cell carcinomas in the eastern Chinese Han population

Abstract

The aim of this case–control study was to assess whether PPARG and IGF2BP2 polymorphisms confer susceptibility to esophageal squamous-cell carcinoma (ESCC). A total of 507 patients pathologically confirmed for ESCC and 1,496 age-, sex-, and residence-matched healthy individuals were enrolled. The PPARG rs1801282 C>G and rs3856806 C>T and IGF2BP2 rs1470579 A>C and rs4402960 G>T polymorphisms were selected and genotyped by SNPscan genotyping assays. Multivariable logistic analysis suggested that the PPARG rs3856806 C>T polymorphism might increase the risk of ESCC. In different stratified analyses, there were significant associations between PPARG rs3856806 C>T and risk of ESCC in female, never-smoking, drinking, and never-drinking subgroups. In addition, we also found that PPARG rs1801282 C>G increased ESCC risk in the never-smoking subgroup. There was significant difference in C_rs1470579G_rs4402960C_rs1801282C_rs3856806-haplotype distribution among ESCC cases and control subjects. In conclusion, our findings highlight that PPARG rs1801282 C>G and rs3856806 C>T polymorphisms are candidates for susceptibility to ESCC in the eastern Chinese Han population. The C_rs1470579G_rs4402960C_rs1801282C_rs3856806 haplotype is associated with susceptibility to ESCC.

Keywords:

• PPARG
• IGF2BP2
• polymorphism
• risk
• ESCC

Acknowledgments

We appreciate all subjects who participated in this study. We wish to thank Dr Yan Liu (Genesky Biotechnologies Inc, Shanghai, China) for technical support. This study was supported in part by the Natural Science Foundation of Universities and Colleges of Jiangsu (grant 16KJB310002), Senior Talents Scientific Research Foundation of Jiangsu University (grant 16JDG066). The Natural Science Foundation of Fujian Province (Grant No 2015J01435, 2017J01259), and the National Clinical Key Specialty Construction Program, Young and Middle-Aged Talent Training Project of the Health Development Planning Commission in Fujian (2016-ZQN-25 and 2014-ZQN-JC-11), Medical Innovation Project of Fujian (2014-CX-15 and 2014-CX-18), Nursery Garden Project of Fujian Medical University (2015MP020), and Science and Technology Project of Fujian (2060203).

Disclosure

The authors report no conflicts of interest in this work.