Adult acute megakaryoblastic leukemia: rare association with cytopenias of undetermined significance and p210 and p190 BCR–ABL transcripts

Abstract

Acute megakaryocytic leukemia (M7-AML) is a rare form of acute myeloid leukemia (AML), which is associated with poor prognosis. The case presented in the current report is a statement for the difficult diagnosis and clinical management of M7-AML in the context of a previous hematologic disorder of undetermined significance and associated genetic abnormalities. Probably, following the complete hematologic remission and further with induction chemotherapy plus tyrosine kinase inhibitor therapy, the clinical management of this case will be followed by a allogeneic bone marrow transplantation, the only proven therapy to improve overall survival.

Keywords:

• acute megakaryocytic leukemia
• BCR–ABL transcript

Acknowledgments

We deeply acknowledge the contribution of Laura-Ancuta Pop, Bobe Petrushev, Mariana Patiu, Sonia Selicean, Grigore-Aristide Gafencu, Wilhelm-Thomas Micu, Daiana Temian, Ancuta Jurj and Ioana Berindan-Neagoe.

Disclosure

Ana-Maria Rosu received funding from an internal grant of the Iuliu Hatieganu University, awarded to Ph.D. students. Ciprian Tomuleasa received funding from the Romanian Research Ministry, contracts PN-II-RU-TE-2014-4-1783 (awarded to young research teams) and CNFIS-FDI-2017-1350 (awarded to institutional development funds), as well as from an international collaboration grant between Romania and People’s Republic of China, contract 57 BM/2016. The authors report no other conflicts of interest in this work.