Abstract
Background
Accumulated studies have evaluated the association of pre-miR-218 rs11134527 polymorphism with cancer risk in Chinese population. However, the results remain controversial.
Methods
To derive a more precise and more comprehensive estimation of the relationship, six studies focused on Chinese population were included for the pooled analysis for pre-miR-218 rs11134527 polymorphism using odds ratios (ORs) with 95% confidence intervals (CIs).
Results
Pre-miR-218 rs11134527 polymorphism was associated with cancer risk (G versus A, OR =0.93, 95% CI: 0.88–0.98; GG versus AG + AA, OR =0.88, 95% CI: 0.79–0.97; GG versus AA, OR =0.85, 95% CI: 0.76–0.96). In the stratified analysis by cancer type, the pre-miR-218 rs11134527 polymorphism was only associated with the risk of cervical cancer (G versus A, OR =0.90, 95% CI: 0.83–0.98; GG versus AG + AA, OR =0.80, 95% CI: 0.68–0.94; GG versus AA, OR =0.79, 95% CI: 0.66–0.94).
Conclusion
These findings suggest that the pre-miR-218 rs11134527 genetic polymorphism may decrease the susceptibility to cervical cancer, which needs to be verified or linked with functional studies.
Disclosure
The authors report no conflicts of interest in this work.