Abstract
Objective
To investigate the role of FBLN5in renal clear cell carcinoma (KIRC), in particular on the tumor’s immune microenvironment, including children and young adults.
Methods
FBLN5 expression in tumor and normal samples was explored using SangerBox, TIMER2.0, GEPIA, UALCAN, HPA databases. The Linkedomics database was used to obtain FBLN5 co-expressed genes in KIRC tissue. SangerBox was also used to estimate immune infiltration of FBLN5 in KIRC. The Kaplan-Meier plotter was used to investigate the survival effects of FBLN5 expression in the presence of immune infiltration. We then collected 48 cases from 7 hospitals over a-20 year period to calculate the impact of FBLN5 on the prognosis of children and young adults with KIRC.
Results
FBLN5 expression was significantly reduced in KIRC tissue compared to normal adjacent tissue. FBLN5 was potentially involved in the immune-related biological processes. In addition, FBLN5 expression has been linked to a number of immune checkpoints, cytokines, chemokines and chemokine receptors in KIRC. At the same time, the expression of FBLN5 affected the survival rates differently in KIRC patients with high or low levels of immune infiltration. High expression of FBLN5 in children and young adults with KIRC was associated with a favorable prognosis.
Conclusion
This study shed light on the potential of FBLN5 as a prognostic marker in children and young adults with KIRC and as an immune-related target for clinical treatment.
Data Sharing Statement
Inquiries can be directed to the corresponding author: Dongsheng Zhu, email: [email protected].
Ethics Statement
The study involving human participants was reviewed and approved by The Ethics Committee of Lianyungang First Hospital approved this study (20220215). Written informed consent was obtained from the participants or guardians of patients younger than 18 years of age. And this study complies with all the rules.
Acknowledgments
Ming Zhang, Feng Chen and Shaoguang Feng are co-first authors and contributed equally to this work.
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Disclosure
The authors report no conflicts of interest in this work.