Abstract
Purpose
To examine the relationship between baseline total knee arthroplasty (TKA) status and patient-reported, knee-related quality of life (QoL) over a 4-year follow-up relative to no knee osteoarthritis (OA).
Patients and methods
Data from the Osteoarthritis Initiative were included, comprising 4,674 adults aged 45–79 years at baseline. Patients were categorized into four groups: no knee OA (n=3,711), non-TKA (n=902), pre-TKA (n=36), and post-TKA (n=25). QoL was measured using the Knee Injury Osteoarthritis Outcome Score-QoL subscale. General linear mixed models were used for the relationship between TKA and QoL.
Results
After adjusting for covariates, a reduced QoL was noted for patients in the non-TKA (mean [standard error], −13.97 [0.73]; P<0.0001), pre-TKA (−21.34 [3.57]; P<0.0001), and post-TKA (−9.68 [3.94]; P=0.0143) groups compared with the no knee OA group. QoL in the non-TKA group also decreased over time (−0.16 [0.07]; P=0.226).
Conclusion
Non-, pre-, and post-TKA status is associated with a lower QoL.
Acknowledgments
The author extends his appreciation to the Research Center, College of Applied Medical Sciences, and the Deanship of Scientific Research at King Saud University for funding this research. The OAI is a public–private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health and Private funding partners. This manuscript was prepared using an OAI public use data set and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partners.
Disclosure
The author reports no conflicts of interest in this work.