Abstract
Objective
The self-reported scale is a widely used method to assess patients’ medication adherence in clinical practice, but there is still a lack of medicine adherence measurement scale for patients with Chronic Kidney Disease (CKD). Therefore, this study aimed to develop a medication adherence measurement scale of traditional Chinese medicine and Western medicine, providing a tool for evaluating medicine adherence of CKD patients.
Methods
In the preliminary stage, we formed the prediction scale after three rounds Delphi method and it was filled by 20 patients, who were selected randomly. After pre-investigation and language adaption, we adjusted the prediction measurement scale which included 31 items based on Knowledge-Attitude-Belief Theory. Then, 222 CKD patients in Guangdong Hospital of traditional Chinese Medicine were investigated by this 31-item scale. We screened 31 items by Items analysis theory, including critical ratio, item correlation analysis, internal consistency analysis, principal component analysis and other methods. The left 26 items made up a formal scale. We collected and analyzed data of the 26-item scale and Chinese version of MGL scale, and took their scores correlation analysis as the criterion validity of the 26-item scale. At the same time, we evaluated content validity, Cronbach alpha coefficient and retest reliability of the 26-item scale.
Results
We developed a scale with 26 items and 5 dimensions finally. In the validation analysis, the scale had good construct validity and content validity. The Pearson relation index between respective scores of the scale and Chinese version of MGL scale was 0.426, P<0.01. The scale also had good reliability as its 0.915 in Cronbach alpha, 0.753 in retest reliability and P<0.01.
Conclusion
The scale revealed great reliability and validity, which could be used as a measurement tool to evaluate the medication adherence of patients with CKD.
Acknowledgments
We greatly thank colleagues from Guangdong Province Hospital of Traditional Chinese Medicine for their contribution to this study. Guangzhou Science and Technology Program key projects: Yi-Fan Wu (2016201604030022); Guangdong Provincial Hospital of Chinese Medicine Program: Yi-Fan Wu (YN2018ZWB04).
Ethics approval
The patients' consent was written informed consent, and this study was conducted in accordance with the Declaration of Helsinki. It was approved by Ethics Committee of Guangdong Provincial Hospital of Chinese Medicine. Petition Number: B2016-93.
Disclosure
The authors report no conflicts of interest in this work.