https://orcid.org/0000-0002-2650-8668
Abstract
Purpose
This study aimed to assess the factors that affect adherence to co-trimoxazole preventive therapy (CPT) among human immunodeficiency virus (HIV)-positive adults in an antiretroviral therapy (ART) clinic at the University of Gondar Compressive Specialized Teaching Hospital (UOGCSTH).
Methods
A hospital-based cross-sectional study was conducted from March 1 to April 30, 2018, at the ART clinic at UOGCSTH. Data were collected using face-to-face interviews with pretested and standard questionnaires. Binary and multivariable logistic regression analyses were used to assess the association between different variables. P<0.05 was used to declare the association.
Results
The prevalence of adherence to CPT by self-reporting measurement was 205 (67.8%). Factors such as level of education, taking street drugs (alcohol and khat), spouse knowledge about clients on CPT, knowledge of the benefit of CPT, duration of CPT, missed dose, got proper information on how to take CPT, and counseling done on refill were found to be significantly associated with adherence to CPT.
Conclusion and Recommendations
The overall adherence to CPT was fair in our study. To improve the adherence, continuous education and counseling, giving group service support for clients and having a separate counseling room are some of the possible solutions.
Abbreviations
AIDS, acquired immune deficiency syndrome; ART, antiretroviral therapy; ADR, adverse drug reaction; CPT, co-trimoxazole preventive therapy; HIV, human immunodeficiency virus; OIs, opportunistic infections; UOGCSTH, University of Gondar Compressive Specialized Teaching Hospital.
Data Sharing Statement
All available data can be obtained by contacting the corresponding author.
Acknowledgments
We would like to thank the data collectors and supervisors involved in data collection and the clients for their participation.
Author Contributions
Both authors of this manuscript made substantial contributions to conception and design, acquisition of data or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; gave final approval of the version to be published; and agree to be accountable for all aspects of the work, including ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Disclosure
Financial support was provided only by the authors. The authors declare that they have no conflicts of interest.